The concept of schizophrenia only covers the 30% poor outcome fraction of a much broader
multidimensional psychotic syndrome, yet paradoxically has become the dominant prism …

Although synaptic loss is thought to be core to the pathophysiology of schizophrenia, the
nature, consistency and magnitude of synaptic protein and mRNA changes has not been …

The study of the life course and human development flourished during the closing decades
of the twentieth century, extending across substantive and theoretical boundaries (Mortimer …

The number and subunit composition of synaptic N-methyl-d-aspartate receptors (NMDARs)
are not static, but change in a cell-and synapse-specific manner during development and in …

Although we have studied schizophrenia as a major disease entity over the past century, its
causes and pathogenesis remain obscure. In this article, we critically review genetic and …

Parkinson's disease is a widespread condition caused by the loss of midbrain neurons that
synthesize the neurotransmitter dopamine. Cells derived from the fetal midbrain can modify …

Oxidative stress has been suggested to contribute to the pathophysiology of schizophrenia.
In particular, oxidative damage to lipids, proteins, and DNA as observed in schizophrenia is …

The psychosis associated with schizophrenia is characterized by alterations in sensory
processing and perception,. Some antipsychotic drugs were identified by their high affinity …

The chapter addresses the stigma associated with mental illnesses. It begins by
summarizing the development of thinking about labeling and stigma over the past half …

BACKGROUND: Glutamate has been thought to have a role in mental disorders. Because
the postmortem interval (PMI) has such a pronounced effect on glutamate and other amino …