T cells are crucial for immune functions to maintain health and prevent disease. T cell
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …

The intestinal epithelial barrier (IEB) is one of the largest interfaces between the
environment and the internal milieu of the body. It is essential to limit the passage of harmful …

Inflammatory bowel disease (IBD) is a chronic and life‐threating inflammatory disease of
gastroenteric tissue characterized by episodes of intestinal inflammation. The pathogenesis …

Inflammatory bowel diseases (IBDs) such as Crohn's disease and ulcerative colitis are
characterized by uncontrolled activation of intestinal immune cells in a genetically …

The discovery of cytokines as key drivers of immune-mediated diseases has spurred efforts
to target their associated signalling pathways. Janus kinases (JAKs) are essential signalling …

These guidelines are a consensus work of a considerable number of members of the
immunology and flow cytometry community. They provide the theory and key practical …

Inflammatory bowel diseases (IBDs) result in diarrhea and abdominal pain with further
potential complications such as tissue fibrosis and stenosis. Animal models help in …

From a technical point of view a flow cytometer is a light detection device capable of
detecting photons of different wavelengths over a high dynamic range. In order to achieve a …

Ulcerative colitis (UC) is a chronic inflammatory disease with an underlying excessive
immune response directed against resident microbiota and/or dietary antigens. Both innate …

A fundamental function of the intestinal epithelium is to act as a barrier that limits interactions
between luminal contents such as the intestinal microbiota, the underlying immune system …