The generation of anti-tumor immunity in the draining lymph nodes is known as the cancer
immunity cycle. Accumulating evidence supports the occurrence of such a cycle at tumor …

T cells can acquire a broad spectrum of differentiation states following activation. At the
extreme ends of this continuum are short-lived cells equipped with effector machinery and …

There is a pressing need for allogeneic chimeric antigen receptor (CAR)-immune cell
therapies that are safe, effective and affordable. We conducted a phase 1/2 trial of cord …

Summary Rewiring exhausted CD8+ T (Tex) cells toward functional states remains a
therapeutic challenge. Tex cells are epigenetically programmed by the transcription factor …

Understanding tumor microenvironment (TME) reprogramming in gastric adenocarcinoma
(GAC) progression may uncover novel therapeutic targets. Here, we performed single-cell …

Tissue imaging has become much more colourful in the past decade. Advances in both
experimental and analytical methods now make it possible to image protein markers in …

Pancreatic ductal adenocarcinoma is associated with a poor prognosis and there are few
treatment options. The development of immunotherapy in pancreatic ductal adenocarcinoma …

Single-cell and spatial multimodal technologies have propelled discoveries of the solid
tumor microenvironment (TME) molecular features and their correlation with clinical …

Abstract Background Pituitary neuroendocrine tumors (PitNETs) are one of the most
common types of intracranial tumors. Currently, the cellular characteristics of normal pituitary …

Spatial omics data allow in-depth analysis of tissue architectures, opening new opportunities
for biological discovery. In particular, imaging techniques offer single-cell resolutions …