The diversity, composition, and function of the bacterial community inhabiting the human
gastrointestinal tract contributes to host health through its role in producing energy or …

The gut microbiota is profoundly involved in glucose and lipid metabolism, in part by
regulating bile acid (BA) metabolism and affecting multiple BA-receptor signaling pathways …

Background Intrahepatic cholestasis of pregnancy, characterised by maternal pruritus and
increased serum bile acid concentrations, is associated with increased rates of stillbirth …

Because of its unique function and anatomical location, the liver is exposed to a multitude of
toxins and xenobiotics, including medications and alcohol, as well as to infection by …

Bile acids (BAs) play a crucial role in nutrient absorption and act as key regulators of lipid
and glucose metabolism and immune homeostasis. Through the enterohepatic circulation …

Inflammatory bowel diseases (IBD) comprise a group of common and debilitating chronic
intestinal disorders for which currently available therapies are often unsatisfactory. The …

Apoptosis is a prominent feature of liver diseases. Causative factors such as alcohol,
viruses, toxic bile acids, fatty acids, drugs, and immune response, can induce apoptotic cell …

Bile acids, mainly ursodeoxycholic acid (UDCA) and its conjugated species
glycoursodeoxycholic acid (GUDCA) and tauroursodeoxycholic acid (TUDCA) have long …

During sepsis, the liver plays a key role. It is implicated in the host response, participating in
the clearance of the infectious agents/products. Sepsis also induces liver damage through …

Abstract Background and Aim Ursodeoxycholic acid (UDCA) treatment is an effective
medical therapy for patients with primary biliary cirrhosis (PBC); however, 40% of PBC …