Scopolamine, an anticholinergic, is an attractive amnesic agent for discerning the action of
candidate antiamnesic drugs. Bacopa monniera Linn (Syn. Brahmi) is one such antiamnesic …

Cancer stem cells (CSCs) play an important role in carcinogenesis, resistance to treatment
and may lead to cancer recurrence and metastasis. However, the molecular mechanism of …

Purpose Dysregulated microRNAs are implicated in the pathogenesis and aggressiveness
of acute myeloid leukemia (AML). We describe the effect of the hematopoietic stem-cell self …

Vitamin A (retinol) is essential for normal regulation of cell growth and differentiation. We
have shown that the retinol metabolite retinoic acid (RA) induces mucous cell differentiation …

Carcinogenesis is a multistep process that converts normal cells into malignant cells. Once
transformed, malignant cells acquire the ability to invade and metastasize, leading to …

Activation of ERK1 and ERK2 protein kinases has been implicated in diverse cellular
processes, including the control of cell proliferation and cell differentiation (Marshall [1995] …

IL-21 is a cytokine known to mediate its biological action via the IL-21R, composed of a
specific chain, IL-21Rα, and the common γ-chain (CD132). Recent data suggest that IL-21 …

All-trans-retinoic acid (RA), a natural metabolite of retinol, carries out most of the biological
activities of vitamin A and is required for normal growth, cell differentiation, and immune …

Retinoic acid (RA) is used to treat leukemia and other cancers through its ability to promote
cancer cell differentiation. Strategies to enhance the anticancer effects of RA could deepen …

Retinoic acid (RA), an active metabolite of vitamin A, is a natural morphogen involved in
development and differentiation of the nervous system. To elucidate signaling mechanisms …