Activation of JNK, p38 and ERK mitogen-activated protein kinases by chromium (VI) is mediated through oxidative stress but does not affect cytotoxicity
SM Chuang, GY Liou, JL Yang - Carcinogenesis, 2000 - academic.oup.com
In this study we have explored the involvement of oxidative stress in Cr (VI)-induced JNK,
p38 and ERK signaling pathways and their effects on Cr (VI) cytotoxicity in human non-small …
p38 and ERK signaling pathways and their effects on Cr (VI) cytotoxicity in human non-small …
Inhibition of p38 MAP kinase activity up-regulates multiple MAP kinase pathways and potentiates 1, 25-dihydroxyvitamin D3-induced differentiation of human leukemia …
X Wang, J Rao, GP Studzinski - Experimental cell research, 2000 - Elsevier
Differentiation therapy for neoplastic diseases has potential for supplementing existing
treatment modalities but its implementation has been slow. One of the reasons is the lack of …
treatment modalities but its implementation has been slow. One of the reasons is the lack of …
B7-H4 enhances oncogenicity and inhibits apoptosis in pancreatic cancer cells
Y Qian, B Hong, L Shen, Z Wu, H Yao, L Zhang - Cell and tissue research, 2013 - Springer
B7-H4 is expressed in a variety of tumor cells and functions as a negative regulator of T
cells. However, clarification is needed as to whether B7-H4 mediates tumorigenesis through …
cells. However, clarification is needed as to whether B7-H4 mediates tumorigenesis through …
[HTML][HTML] Combination of midostaurin and ATRA exerts dose-dependent dual effects on acute myeloid leukemia cells with wild type FLT3
H Lu, X Weng, Y Sheng, J Wu, H Xi, X Cai - BMC cancer, 2022 - Springer
Background Midostaurin combined with chemotherapy is currently used to treat newly
diagnosed acute myeloid leukemia (AML) patients with FMS-like tyrosine kinase 3 (FLT3) …
diagnosed acute myeloid leukemia (AML) patients with FMS-like tyrosine kinase 3 (FLT3) …
Retinoic acid differentially regulates cancer cell proliferation via dose-dependent modulation of the mitogen-activated protein kinase pathway
DL Crowe, R Kim, RAS Chandraratna - Molecular cancer research, 2003 - AACR
The chemotherapeutic agent retinoic acid (RA) and its derivatives have been used to treat
many tumor types. The antitumor effects of retinoids are in part due to their ability to inhibit …
many tumor types. The antitumor effects of retinoids are in part due to their ability to inhibit …
Morphogens and blood-brain barrier function in health and disease
NR Wevers, HE de Vries - Tissue barriers, 2016 - Taylor & Francis
The microvasculature of the brain forms a protective blood-brain barrier (BBB) that ensures a
homeostatic environment for the central nervous system (CNS), which is essential for …
homeostatic environment for the central nervous system (CNS), which is essential for …
[HTML][HTML] Novel insights into the role of kras in myeloid differentiation: engaging with Wnt/β-catenin signaling
N Yokoyama, H Nakayama, K Iwabuchi - Cells, 2023 - mdpi.com
Cells of the HL-60 myeloid leukemia cell line can be differentiated into neutrophil-like cells
by treatment with dimethyl sulfoxide (DMSO). The molecular mechanisms involved in this …
by treatment with dimethyl sulfoxide (DMSO). The molecular mechanisms involved in this …
[HTML][HTML] Role of the p38 mitogen-activated protein kinase pathway in the generation of the effects of imatinib mesylate (STI571) in BCR-ABL-expressing cells
S Parmar, E Katsoulidis, A Verma, Y Li… - Journal of Biological …, 2004 - ASBMB
Imatinib mesylate (STI571), a specific inhibitor of the BCR-ABL tyrosine kinase, exhibits
potent antileukemic effects in vitro and in vivo. Despite the well established role of STI571 in …
potent antileukemic effects in vitro and in vivo. Despite the well established role of STI571 in …
Activation of extracellular regulated kinases (ERK1/2) but not AKT predicts poor prognosis in colorectal carcinoma and is associated with k-ras mutations
KJ Schmitz, J Wohlschlaeger, H Alakus, J Bohr… - Virchows Archiv, 2007 - Springer
Signal transduction and modulation represent central mechanisms in cellular processes
such as cell-cycle regulation, oncogenesis, and apoptosis. The aim of this study was to …
such as cell-cycle regulation, oncogenesis, and apoptosis. The aim of this study was to …
EGFR inhibitors exacerbate differentiation and cell cycle arrest induced by retinoic acid and vitamin D3 in acute myeloid leukemia cells
E Lainey, A Wolfromm, AQ Sukkurwala, JB Micol… - Cell Cycle, 2013 - Taylor & Francis
By means of an unbiased, automated fluorescence microscopy-based screen, we identified
the epidermal growth factor receptor (EGFR) inhibitors erlotinib and gefitinib as potent …
the epidermal growth factor receptor (EGFR) inhibitors erlotinib and gefitinib as potent …