The business of defending the body against invading microorganisms relies heavily on the
action of monocytes/macrophages and granulocytes (also called neutrophils). These …

Vitamin A, its physiological metabolites and synthetic derivatives (retinoids) have been
shown to have protective effects against the development of certain types of cancer. In …

Background: Ethanol is the main addictive and neurotoxic constituent of alcohol. Ethanol
exposure during embryonic development causes dysfunction of the central nervous system …

Retinoic acid (RA) is known to cause the myeloid differentiation of HL-60 human
myeloblastic leukemia cells in a process requiring MEK-dependent ERK2 activation. This …

Among the three major mitogen-activated protein kinase (MAPK) cascades—the
extracellular signal regulated kinase (ERK) pathway, the c-JUN N-terminal/stress-activated …

Onzin is a small, novel, and highly conserved protein with unique structure and tissue-
restricted expression. The regulation of its expression and biological roles remain greatly …

Retinoic acid (RA) is known to regulate cell growth and differentiation. In HL-60 human
myeloblastic leukemia cells, it causes mitogen-activated protein kinase (MAPK) signaling …

Although tamoxifen (TAM), which is widely used in the treatment of breast cancer, also has a
beneficial effect on cisplatin-refractory ovarian cancer, the biological mechanism of this …

Three heteroarotinoids containing a nitrogen atom in the first ring and a C− O linking group
between the two aryl rings were synthesized and evaluated for RAR and RXR retinoid …

Monocytic differentiation of HL60 cells induced by 1, 25‐dihydroxyvitamin D3 (1, 25 D3) has
been recently shown (Exp Cell Res 258, 425, 2000) to be enhanced by an exposure to …