Perineuronal nets (PNNs) are extracellular matrix (ECM) chondroitin sulfate proteoglycan
(CSPG)-containing structures that surround the soma and dendrites of various mammalian …

Perineuronal nets (PNNs) are unique extracellular matrix structures that wrap around certain
neurons in the CNS during development and control plasticity in the adult CNS. They appear …

All cells sense and integrate mechanical and biochemical cues from their environment to
orchestrate organismal development and maintain tissue homeostasis …

Sulfation is a dynamic and complex posttranslational modification process. It can occur at
various positions within the glycosaminoglycan (GAG) backbone and modulates …

Alzheimer's disease (AD) is a neurodegenerative disease with complex pathological
characteristics, whose etiology and pathogenesis are still unclear. Over the past few …

Although neurons attract the most attention in neurobiology, our current knowledge of neural
circuit can only partially explain the neurological and psychiatric conditions of the brain …

Perineuronal nets (PNNs) in the brain are condensed glycosaminoglycan-rich extracellular
matrix structures with heterogeneous composition yet specific organization. They typically …

The synaptic transmission in the mammalian brain is not limited to the interplay between the
pre-and the postsynapse of neurons, but involves also astrocytes as well as extracellular …

Reactive astrocytes have been proposed to become incompetent bystanders in epilepsy as
a result of cellular changes rendering them unable to perform important housekeeping …

Glycosaminoglycans (GAGs) are a heterogeneous family of linear polysaccharides which
are composed of a repeating disaccharide unit. They are also linked to core proteins to form …