Background Hip fractures are associated with a high risk of death; among those who survive
a hip fracture, many experience substantial decreases in quality of life. A comprehensive …

Background Traumatic amputation leads to disability and imposes a heavy health burden.
This study aims to explore the current status and temporal trends of the global burden of …

Activating Nrf2 by small molecules is a promising strategy to treat postmenopausal
osteoporosis. However, there is currently no Nrf2 activator approved for treating chronic …

Background We aimed to document the current state of exposure to low bone mineral
density (BMD) and trends in attributable burdens between 2000 and 2019 globally and in …

Although the impact of sex hormones on bone metabolism is well‐documented, effect of
their primary modulator, sex hormone‐binding globulin (SHBG), remains inconclusive. This …

Objective We aim to explore the prevalence and temporal trends of the burden of kidney
dysfunction (KD) in global, regional and national level, since a lack of related studies …

Abstract cytohesin-2 is a guanine nucleotide exchange factor to activate ARF1 and ARF6,
which are involved in various biological processes, including signal transduction, cell …

Aim Our study aimed to survey the burden of disease attributed to metabolic risks (MRs) and
secondary MR from 1990 to 2019. Methods Using methodological framework of the Global …

Introduction Patients with haemophilia (PWH) may have lower bone mineral density (BMD).
The risk of low BMD in PWH has not been comprehensively analysed. This study aimed to …

Osteoclasts consume an amount of adenosine triphosphate (ATP) to perform their bone
resorption function in the development of osteoporosis. However, the mechanism underlying …