An overview of NO signaling pathways in aging

AM Pourbagher-Shahri, T Farkhondeh, M Talebi… - Molecules, 2021 - mdpi.com
Nitric Oxide (NO) is a potent signaling molecule involved in the regulation of various cellular
mechanisms and pathways under normal and pathological conditions. NO production, its …

Dietary supplements and natural products: an update on their clinical effectiveness and molecular mechanisms of action during accelerated biological aging

Y Chen, S Hamidu, X Yang, Y Yan, Q Wang, L Li… - Frontiers in …, 2022 - frontiersin.org
Accelerated biological aging, which involves the gradual decline of organ or tissue functions
and the distortion of physiological processes, underlies several human diseases. Away from …

Anti-Alzheimers molecular mechanism of icariin: insights from gut microbiota, metabolomics, and network pharmacology

Y Liu, H Li, X Wang, J Huang, D Zhao, Y Tan… - Journal of translational …, 2023 - Springer
Background Icariin (ICA), an active ingredient extracted from Epimedium species, has
shown promising results in the treatment of Alzheimer's disease (AD), although its potential …

[HTML][HTML] Icariin alleviates uveitis by targeting peroxiredoxin 3 to modulate retinal microglia M1/M2 phenotypic polarization

G Wang, X Li, N Li, X Wang, S He, W Li, W Fan, R Li… - Redox biology, 2022 - Elsevier
Uveitis causes blindness and critical visual impairment in people of all ages, and retinal
microglia participate in uveitis progression. Unfortunately, effective treatment is deficient …

Digestion under saliva, simulated gastric and small intestinal conditions and fermentation in vitro by human gut microbiota of polysaccharides from Ficus carica Linn.

B Xu, S Song, L Yao, H Wang, M Sun, H Zhuang… - Food …, 2024 - Elsevier
Previous studies have shown that Ficus carica polysaccharide (FCPS) extracted from
common fig fruit exhibits antioxidant and immune-enhancing properties. Nevertheless, it …

[HTML][HTML] Jiangu granule ameliorated OVX rats bone loss by modulating gut microbiota-SCFAs-Treg/Th17 axis

P Sun, C Zhang, Y Huang, J Yang, F Zhou… - Biomedicine & …, 2022 - Elsevier
Background Postmenopausal osteoporosis (PMOP) is a common disease that has
decreased bone strength as its main symptom after menopause. Effective treatment for …

[HTML][HTML] Dietary neoagarotetraose extends lifespan and impedes brain aging in mice via regulation of microbiota-gut-brain axis

T Li, S Yang, X Liu, Y Li, Z Gu, Z Jiang - Journal of Advanced Research, 2023 - Elsevier
Introduction Dietary oligosaccharides can impact the gut microbiota and confer tremendous
health benefits. Objectives The aim of this study was to determine the impact of a novel …

Unveiling the impact of Aging on BBB and Alzheimer's disease: Factors and Therapeutic implications

VK Nelson, NK Jha, MV Nuli, S Gupta, S Kanna… - Ageing research …, 2024 - Elsevier
Alzheimer's disease (AD) is a highly prevalent neurodegenerative condition that has
devastating effects on individuals, often resulting in dementia. AD is primarily defined by the …

[HTML][HTML] The neuroprotective effects of icariin on ageing, various neurological, neuropsychiatric disorders, and brain injury induced by radiation exposure

LR Li, G Sethi, X Zhang, CL Liu, Y Huang, Q Liu… - Aging (Albany …, 2022 - ncbi.nlm.nih.gov
Abstract Epimedium brevicornum Maxim, a Traditional Chinese Medicine, has been used for
the treatment of impotence, sinew and bone disorders,“painful impediment caused by wind …

Poria cocos polysaccharides exert prebiotic function to attenuate the adverse effects and improve the therapeutic outcome of 5-FU in ApcMin/+ mice

L Yin, G Huang, I Khan, L Su, W Xia, BYK Law… - Chinese medicine, 2022 - Springer
Background As a first-line chemotherapeutic agent, 5-fluorouracil (5-FU) exhibits many side
effects, weakening its efficacy in cancer treatment. In this study, we hypothesize that Poria …