[HTML][HTML] Translating phage therapy into the clinic: Recent accomplishments but continuing challenges

A Petrovic Fabijan, J Iredell, K Danis-Wlodarczyk… - Plos …, 2023 - journals.plos.org
Phage therapy is a medical form of biological control of bacterial infections, one that uses
naturally occurring viruses, called bacteriophages or phages, as antibacterial agents …

[HTML][HTML] Gut liver brain axis in diseases: the implications for therapeutic interventions

M Yan, S Man, B Sun, L Ma, L Guo, L Huang… - Signal Transduction and …, 2023 - nature.com
Gut-liver-brain axis is a three-way highway of information interaction system among the
gastrointestinal tract, liver, and nervous systems. In the past few decades, breakthrough …

[HTML][HTML] Current clinical landscape and global potential of bacteriophage therapy

NM Hitchcock, D Devequi Gomes Nunes, J Shiach… - Viruses, 2023 - mdpi.com
In response to the global spread of antimicrobial resistance, there is an increased demand
for novel and innovative antimicrobials. Bacteriophages have been known for their potential …

[HTML][HTML] Phage therapy—challenges, opportunities and future prospects

B Zalewska-Piątek - Pharmaceuticals, 2023 - mdpi.com
The increasing drug resistance of bacteria to commonly used antibiotics creates the need to
search for and develop alternative forms of treatment. Phage therapy fits this trend perfectly …

The mechanism of the phage-encoded protein antibiotic from ΦX174

AK Orta, N Riera, YE Li, S Tanaka, HG Yun, L Klaic… - Science, 2023 - science.org
The historically important phage ΦX174 kills its host bacteria by encoding a 91-residue
protein antibiotic called protein E. Using single-particle electron cryo–microscopy, we …

Emerging strategies for combating Fusobacterium nucleatum in colorectal cancer treatment: Systematic review, improvements and future challenges

H Liu, Y Yu, A Dong, M Elsabahy, YW Yang… - Exploration, 2024 - Wiley Online Library
Colorectal cancer (CRC) is generally characterized by a high prevalence of Fusobacterium
nucleatum (F. nucleatum), a spindle‐shaped, Gram‐negative anaerobe pathogen derived …

[HTML][HTML] Bacteriophage adsorption: Likelihood of virion encounter with bacteria and other factors affecting rates

ST Abedon - Antibiotics, 2023 - mdpi.com
For ideal gasses, the likelihood of collision of two molecules is a function of concentrations
as well as environmental factors such as temperature. This too is the case for particles …

Slow growing bacteria survive bacteriophage in isolation

EL Attrill, U Łapińska, ER Westra… - ISME …, 2023 - academic.oup.com
The interactions between bacteria and bacteriophage have important roles in the global
ecosystem; in turn changes in environmental parameters affect the interactions between …

[HTML][HTML] Topical phage therapy in a mouse model of Cutibacterium acnes-induced acne-like lesions

A Rimon, C Rakov, V Lerer, S Sheffer-Levi… - Nature …, 2023 - nature.com
Acne vulgaris is a common neutrophil-driven inflammatory skin disorder in which
Cutibacterium acnes (C. acnes) is known to play a key role. For decades, antibiotics have …

[HTML][HTML] Positive and negative aspects of bacteriophages and their immense role in the food chain

SA Ranveer, V Dasriya, MF Ahmad, HS Dhillon… - npj Science of …, 2024 - nature.com
Bacteriophages infect and replicate inside a bacterial host as well as serve as natural bio-
control agents. Phages were once viewed as nuisances that caused fermentation failures …