Neuroinflammation and COVID-19

A Vanderheiden, RS Klein - Current opinion in neurobiology, 2022 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19) has caused a historic pandemic of
respiratory disease. COVID-19 also causes acute and post-acute neurological symptoms …

Nonresolving inflammation redux

C Nathan - Immunity, 2022 - cell.com
Nonresolving inflammation contributes to many diseases, including COVID-19 in its fatal and
long forms. Our understanding of inflammation is rapidly evolving. Like the immune system …

Morphological, cellular, and molecular basis of brain infection in COVID-19 patients

F Crunfli, VC Carregari, FP Veras… - Proceedings of the …, 2022 - National Acad Sciences
Although increasing evidence confirms neuropsychiatric manifestations associated mainly
with severe COVID-19 infection, long-term neuropsychiatric dysfunction (recently …

Comprehensive clinical assessment identifies specific neurocognitive deficits in working-age patients with long-COVID

DA Holdsworth, R Chamley, R Barker-Davies… - PLoS …, 2022 - journals.plos.org
Introduction There have been more than 425 million COVID-19 infections worldwide. Post-
COVID illness has become a common, disabling complication of this infection. Therefore, it …

SARS-CoV-2 brain regional detection, histopathology, gene expression, and immunomodulatory changes in decedents with COVID-19

GE Serrano, JE Walker, C Tremblay… - … of Neuropathology & …, 2022 - academic.oup.com
Brains of 42 COVID-19 decedents and 107 non-COVID-19 controls were studied. RT-PCR
screening of 16 regions from 20 COVID-19 autopsies found SARS-CoV-2 E gene viral …

Long COVID, neuropsychiatric disorders, psychotropics, present and future

SW Tang, BE Leonard, DM Helmeste - Acta neuropsychiatrica, 2022 - cambridge.org
Long COVID refers to the lingering symptoms which persist or appear after the acute illness.
The dominant long COVID symptoms in the two years since the pandemic began (2020 …

Neurogenesis is disrupted in human hippocampal progenitor cells upon exposure to serum samples from hospitalized COVID-19 patients with neurological symptoms

A Borsini, B Merrick, J Edgeworth, G Mandal… - Molecular …, 2022 - nature.com
Abstract Coronavirus disease 2019 (COVID-19), represents an enormous new threat to our
healthcare system and particularly to the health of older adults. Although the respiratory …

Is central sensitisation the missing link of persisting symptoms after COVID-19 infection?

L Goudman, A De Smedt, M Noppen… - Journal of clinical …, 2021 - mdpi.com
Patients recovered from a COVID-19 infection often report vague symptoms of fatigue or
dyspnoea, comparable to the manifestations in patients with central sensitisation. The …

Cognitive impairment in long-COVID and its association with persistent dysregulation in inflammatory markers

RF Damiano, CCA Rocca, AP Serafim… - Frontiers in …, 2023 - frontiersin.org
Objective To analyze the potential impact of sociodemographic, clinical and biological
factors on the long-term cognitive outcome of patients who survived moderate and severe …

SARS-CoV-2 infects epithelial cells of the blood-cerebrospinal fluid barrier rather than endothelial cells or pericytes of the blood-brain barrier

C Stüdle, H Nishihara, S Wischnewski… - Fluids and Barriers of …, 2023 - Springer
Background As a consequence of SARS-CoV-2 infection various neurocognitive and
neuropsychiatric symptoms can appear, which may persist for several months post infection …