Nanopore-based sensors typically work by monitoring transient pulses in conductance via
current–time traces as molecules translocate through the nanopore. The unique property of …

Nanopore platform holds a great fascination that attracts increasing interests in research and
leads the development of various domains. Herein we first briefly introduce the …

Tremendous efforts have been dedicated to detect single-molecule based on nanopore
technologies. The electrochemical method is now the most widely-used detection scheme of …

Soluble oligomers of amyloid-forming proteins are implicated as toxic species in the context
of several neurodegenerative diseases. Since the size and shape of these oligomers …

In this work, early-stage Aβ42 aggregates were detected using a real-time fast amyloid
seeding and translocation (RT-FAST) assay. Specifically, Aβ42 monomers were incubated …

The development of novel methodologies that can detect biomarkers from cancer or other
diseases is both a challenge and a need for clinical applications. This partly motivates efforts …

Nanopore electrochemical sensors have been developed to detect various emerging
pollutants at the single-molecule level with high sensitivity and specificity due to their high …

In this work, we aim to capture, detect and analysis at single molecule level Aβ42
aggregates. To this end, two strategies of track-etched nanopore membranes …

Biological nanopore-based single-molecule detection technology has shown ultrahigh
sensitivity to various target analyte. But the detection scope of interesting targets is limited …

Disease diagnosis, especially for early diagnosis, is the most effective method to prevent
disease development and mortality. However, low abundance clinical biomarkers in …