Diabetic sensorimotor peripheral neuropathy (DSPN) is a serious complication of diabetes
mellitus and is associated with increased mortality, lower-limb amputations and distressing …

Diabetic peripheral neuropathy (DPN) occurs in up to half of individuals with type 1 or type 2
diabetes. DPN results from the distal-to-proximal loss of peripheral nerve function, leading to …

The upcoming 11th revision of the International Statistical Classification of Diseases and
Related Health Problems (ICD) of the World Health Organization (WHO) offers a unique …

Interactions between the immune and nervous systems are of central importance in
neuropathic pain, a common and debilitating form of chronic pain caused by a lesion or …

Executive summary Every infant, child, and adolescent will experience pain at times
throughout their life. Childhood pain ranges from acute to chronic, and includes procedural …

Neuropathic pain remains a significant unmet medical need. Several recommendations
have recently been proposed concerning pharmacotherapy, neurostimulation techniques …

Primary somatosensory neurons are specialized to transmit specific types of sensory
information through differences in cell size, myelination, and the expression of distinct …

Acute nociceptive pain is a key defence system that enables the detection of danger signals
that threaten homeostasis and survival. However, chronic pain (such as the neuropathic …

Neuropathic pain is characterized by abnormal hypersensitivity to stimuli (hyperalgesia) and
nociceptive responses to non-noxious stimuli (allodynia). The conditions and the …

Piperidines are among the most important synthetic fragments for designing drugs and play
a significant role in the pharmaceutical industry. Their derivatives are present in more than …