Partners in health and disease: pineal gland and purinergic signalling
In mammal's pineal glands, ATP interacts with the high-affinity P2Y1 and the low-affinity
P2X7 receptors. ATP released from sympathetic nerve terminals potentiates noradrenaline …
P2X7 receptors. ATP released from sympathetic nerve terminals potentiates noradrenaline …
[HTML][HTML] Distinct Olfactory Mucosal Macrophage Populations Mediate Neuronal Maintenance and Pathogen Defense
The olfactory mucosa is important for both the sense of smell and as a mucosal immune
barrier to the upper airway and brain. However, little is known about how the immune system …
barrier to the upper airway and brain. However, little is known about how the immune system …
TRPV4-Expressing Tissue-Resident Macrophages Regulate the Function of Collecting Lymphatic Vessels via Thromboxane A2 Receptors in Lymphatic Muscle Cells
ME Schulz, VL Akerstrom, K Song, SE Broyhill, M Li… - bioRxiv, 2024 - biorxiv.org
Rationale: TRPV4 channels are critical regulators of blood vascular function and have been
shown to be dysregulated in many disease conditions in association with inflammation and …
shown to be dysregulated in many disease conditions in association with inflammation and …
Deficiency of the hemoglobin-haptoglobin receptor, CD163, worsens insulin sensitivity in obese male mice
Excessive iron accumulation in metabolic organs such as the adipose tissue, liver, and
skeletal muscle is associated with increased diabetes risk. Tissue-resident macrophages …
skeletal muscle is associated with increased diabetes risk. Tissue-resident macrophages …
Peromyscus leucopus, Mus musculus, and humans have distinct transcriptomic responses to larval Ixodes scapularis bites
JS Bourgeois, JE McCarthy, SP Turk, Q Bernard… - bioRxiv, 2024 - biorxiv.org
Ixodes scapularis ticks are an important vector for at least six tick-borne human pathogens,
including the predominant North American Lyme disease spirochete Borrelia burgdorferi …
including the predominant North American Lyme disease spirochete Borrelia burgdorferi …