Synthetic gene drives, inspired by natural selfish genetic elements and transmitted to
progeny at super-Mendelian (> 50%) frequencies, present transformative potential for …

Chronic hepatitis B virus (HBV) infection is a major cause of liver cirrhosis and liver cancer,
despite strong prevention and treatment efforts. The study of the epigenetic modification of …

The contrasting genome size between homosporous and heterosporous plants is
fascinating. Different from the heterosporous seed plants and mainly homosporous ferns, the …

Immunogenomic loci remain poorly understood because of their genetic complexity and
size. Here, we report the de novo assembly of a cattle genome and provide a detailed …

Background There is insufficient evidence for the ability of vitamin K2 to improve type 2
diabetes mellitus symptoms by regulating gut microbial composition. Herein, we aimed to …

As the most pervasive epigenetic marker present on mRNAs and long non-coding RNAs
(lncRNAs), N 6-methyladenosine (m6A) RNA methylation has been shown to participate in …

Objectives The discrepancy between supply and demand of organ has led to an increased
utilization of steatotic liver for liver transplantation (LT). Hepatic steatosis, however, is a …

Background Salt stress is one of the key factors limiting rice production. Alginate
oligosaccharides (AOS) enhance plant stress resistance. However, the molecular …

Self-incompatibility (SI) is a widespread genetically determined system in flowering plants
that prevents self-fertilization to promote gene flow and limit inbreeding. S-RNase–based SI …

Cas12a can process multiple sgRNAs from a single transcript of CRISPR array, conferring
advantages in multiplexed base editing when incorporated into base editor systems, which …