Significance: Mitochondria produce most of the cellular ATP through the process of oxidative
phosphorylation. Energy metabolism in the mitochondria is associated with the production of …

Microbial community circadian rhythms have a broad influence on host health and even
though light-induced environmental fluctuations could regulate microbial communities, the …

Circadian clocks coordinate mammalian behavior and physiology enabling organisms to
anticipate 24-hour cycles. Transcription-translation feedback loops are thought to drive …

Period (PER) proteins are essential components of the mammalian circadian clock. They
form complexes with cryptochromes (CRY), which negatively regulate CLOCK/BMAL1 …

Circadian timekeeping systems drive oscillatory gene expression to regulate essential
cellular and physiological processes. When the systems are perturbed, pathological …

Life on Earth evolved in the presence of hydrogen peroxide, and other peroxides also
emerged before and with the rise of aerobic metabolism. They were considered only as toxic …

Our understanding of the involvement of the gut microbiota (GM) in human health has
expanded exponentially over the last few decades, particularly in the fields of metabolism …

Patients admitted to the intensive care unit (ICU) are in need of continuous organ
replacement strategies and specialized care, for example because of neurological …

Proteomics holds great promise for understanding human physiology, developing health
biomarkers, and precision medicine. However, how much the plasma proteome varies with …

Chronobiological studies of prokaryotic organisms have generally lagged far behind the
study of endogenous circadian clocks in eukaryotes, in which such systems are essentially …