Depression is one of the most frequent and burdensome non-motor symptoms in
Parkinson's disease (PD), across all stages. Even when its severity is mild, PD depression …

Parkinson's Disease (PD) affects speech in the form of dysphonia and hypokinetic
dysarthria. Multiple studies have evaluated PD's influence on different aspects of speech …

Subthalamic deep brain stimulation (DBS) for Parkinson disease (PD) currently requires
laborious open-loop programming, which can mitigate the benefits of this treatment …

RESUMO A doença de Parkinson é a segunda doença neurodegenerativa mais comum,
tendo sido documentado um aumento significativo da sua prevalência nas últimas três …

In Parkinson's disease, the progressive neurodegeneration of nigrostriatal dopaminergic
neurons in the substantia nigra pars compacta (SNc) is associated with classic motor …

The terms “on” and “off” were used by Marsden and his contemporaries over 40 years ago to
describe times when Parkinson's disease patients experienced good motor function (“on”) …

Background Although subthalamic stimulation is a recognised treatment for motor
complications in Parkinson's disease, reports on behavioural outcomes are controversial …

Dopamine replacement therapy with l-DOPA is the most efficacious symptomatic treatment
for Parkinson's disease, but its utility is limited by a development of motor fluctuations and …

Background Non‐motor symptoms (NMS) are frequent in Parkinson's disease (PD).
Objectives To estimate the prevalence of NMS and of non‐motor fluctuations (NMF) using …

Parkinson's disease is the second most common neurodegenerative disorder, and a
significant increase in its prevalence in the past three decades has been documented …