Neurodevelopmental disturbances in schizophrenia: evidence from genetic and environmental factors
Since more than 3 decades, schizophrenia (SZ) has been regarded as a
neurodevelopmental disorder. The neurodevelopmental hypothesis proposes that SZ is …
neurodevelopmental disorder. The neurodevelopmental hypothesis proposes that SZ is …
Ethical, legal, and social implications of genetic risk prediction for multifactorial disease: a narrative review identifying concerns about interpretation and use of …
CR Chapman - Journal of Community Genetics, 2023 - Springer
Advances in genomics have enabled the development of polygenic scores (PGS),
sometimes called polygenic risk scores, in the context of multifactorial diseases and …
sometimes called polygenic risk scores, in the context of multifactorial diseases and …
Linking polygenic risk of schizophrenia to variation in magnetic resonance imaging brain measures: a comprehensive systematic review
Background and hypothesis Schizophrenia is highly heritable, with a polygenic effect of
many genes conferring risk. Evidence on whether cumulative risk also predicts alterations in …
many genes conferring risk. Evidence on whether cumulative risk also predicts alterations in …
Proteomic profiling in the progression of psychosis: analysis of clinical high-risk, first episode psychosis, and healthy controls
Background and hypothesis Recent evidence has highlighted the benefits of early detection
and treatment for better clinical outcomes in patients with psychosis. Biological markers of …
and treatment for better clinical outcomes in patients with psychosis. Biological markers of …
Geographical variation in treated psychotic and other mental disorders in Finland by region and urbanicity
Abstract Purpose In Finland, prevalence of schizophrenia is higher in the eastern and
northern regions and co-occurs with the distribution of schizophrenia polygenic risk scores …
northern regions and co-occurs with the distribution of schizophrenia polygenic risk scores …
Integration of whole-exome sequencing and structural neuroimaging analysis in major depressive disorder: a joint study
Major depressive disorder (MDD) is a common mental illness worldwide and is triggered by
an intricate interplay between environmental and genetic factors. Although there are several …
an intricate interplay between environmental and genetic factors. Although there are several …
Neuroimaging and epigenetic analysis reveal novel epigenetic loci in major depressive disorder
BackgroundEpigenetic modifications, such as DNA methylation, contribute to the
pathophysiology of major depressive disorder (MDD). This study aimed to identify novel …
pathophysiology of major depressive disorder (MDD). This study aimed to identify novel …
New clues for the role of cerebellum in schizophrenia and the associated cognitive impairment
Schizophrenia (SZ) is a complex neuropsychiatric disorder associated with severe cognitive
dysfunction. Although research has mainly focused on forebrain abnormalities, emerging …
dysfunction. Although research has mainly focused on forebrain abnormalities, emerging …
[HTML][HTML] Increased grey matter volumes in the temporal lobe and its relationship with cognitive functioning in euthymic patients with bipolar disorder
Background Bipolar disorder (BD) is characterized by episodic mood dysregulation,
although a significant portion of patients suffer persistent cognitive impairment during …
although a significant portion of patients suffer persistent cognitive impairment during …
Whole Genome Sequencing Revealed Inherited Rare Oligogenic Variants Contributing to Schizophrenia and Major Depressive Disorder in Two Families
IH Chung, YS Huang, TH Fang, CH Chen - International Journal of …, 2023 - mdpi.com
Schizophrenia and affective disorder are two major complex mental disorders with high
heritability. Evidence shows that rare variants with significant clinical impacts contribute to …
heritability. Evidence shows that rare variants with significant clinical impacts contribute to …