Mechanical signals protect stem cell lineage selection, preserving the bone and muscle phenotypes in obesity

DM Frechette, D Krishnamoorthy… - Annals of the New …, 2017 - Wiley Online Library
The incidence of obesity is rapidly rising, increasing morbidity and mortality rates worldwide.
Associated comorbidities include type 2 diabetes, heart disease, fatty liver disease, and …

Biomechanical analysis of a lacunar-canalicular system under different cyclic displacement loading

Y Wang, H Dong, Y Yan, J Yu, X Wu… - Computer Methods in …, 2023 - Taylor & Francis
The objective of this study is to use the finite element (FE) method to predict the mechanical
signals (interstitial fluid velocity, strain, pore pressure, and pore fluid velocity) produced by …

[HTML][HTML] Differential effects of low-magnitude high-frequency vibration on reloading hind-limb soleus and gastrocnemius medialis muscles in 28-day tail-suspended …

KT Sun, KS Leung, PMF Siu, L Qin… - … of Musculoskeletal & …, 2015 - ncbi.nlm.nih.gov
Objectives: Low-magnitude high-frequency vibration (LMHFV) was reported beneficial to
muscle contractile functions in clinical and preclinical studies. This study aims to investigate …

Multiscale investigation on the effects of additional weight bearing in combination with low-magnitude high-frequency vibration on bone quality of growing female rats

T Zhang, J Gao, J Fang, H Gong - Journal of Bone and Mineral Metabolism, 2018 - Springer
This study aimed to explore the effects of additional weight bearing in combination with low-
magnitude high-frequency vibration (LMHFV; 45 Hz, 0.3 g) on bone quality. One hundred …

Considerations for small animal physical rehabilitation

SM Greising, AM Basten, AG Schifino… - … Rehabilitation: From Basic …, 2022 - Springer
Translational and preclinical investigations of regenerative rehabilitation approaches are
dependent on an ability to appropriately design and implement physical rehabilitation …

Effect of capillary shear stress on recovery and osteogenic differentiation of muscle‐derived precursor cell populations

H Mulhall, M Patel, K Alqahtani… - Journal of tissue …, 2011 - Wiley Online Library
Both chemical and physical stimuli can influence the fate of precursor cell populations.
Therefore, the impact they have on promoting unwanted differentiation events must be …

[HTML][HTML] Effects of immobilization and whole-body vibration on rat serum Type I collagen turnover

G Dönmez, MN Doral, Ş Suljevic, MF Sargon… - Acta orthopaedica et …, 2016 - Elsevier
Objective The aim of this study was to investigate the effects of short-term, high-magnitude
whole-body vibration (WBV) on serum type I collagen turnover in immobilized rats. Materials …

Short-term effects of whole-body vibration on the soleus of ooforectomized rats: Histomorphometric analysis and oxidative stress in an animal model

AL Peretti, CMM Kakihata, AL de Freitas Tavares… - Acta …, 2020 - Elsevier
Purpose The aim of this study was to analyze the effects of mechanical vibration on the
histomorphometry and oxidative stress of oophorectomized rats. Method Seventy-two Wistar …

Skeletal muscle contractions uncoupled from gravitational loading directly increase cortical bone blood flow rates in vivo

C Caulkins, E Ebramzadeh… - Journal of Orthopaedic …, 2009 - Wiley Online Library
The direct and indirect effects of muscle contraction on bone microcirculation and fluid flow
are neither well documented nor explained. However, skeletal muscle contractions may …

Exercise and the prevention of osteoporosis

C T. Rubin, J Rubin, S Judex - Primer on the metabolic bone …, 2013 - Wiley Online Library
Osteopenia, a condition of diminished bone mass, becomes osteoporosis when mechanical
demands exceed the ability of the skeletal structure to support them. Mechanical signals …