Therapeutic role of immunomodulators during the COVID-19 pandemic–a narrative review

H Al-Hajeri, F Baroun, F Abutiban… - Postgraduate …, 2022 - Taylor & Francis
The emergency state caused by COVID-19 saw the use of immunomodulators despite the
absence of robust research. To date, the results of relatively few randomized controlled trials …

Immunouniverse of SARS-CoV-2

D Jiménez, M Torres Arias - Immunological Medicine, 2022 - Taylor & Francis
SARS-CoV-2 virus has become a global health problem that has caused millions of deaths
worldwide. The infection can present with multiple clinical features ranging from …

Effect of polyphenols against complications of COVID-19: current evidence and potential efficacy

M Vajdi, A Karimi, S Hassanizadeh, MA Farhangi… - Pharmacological …, 2024 - Springer
The COVID-19 pandemic that started in 2019 and resulted in significant morbidity and
mortality continues to be a significant global health challenge, characterized by …

[HTML][HTML] Vitamin D deficiency prevalence in hospitalized patients with COVID-19 significantly decreased during the pandemic in Slovakia from 2020 to 2022 which was …

J Smaha, P Jackuliak, M Kužma, F Max, N Binkley… - Nutrients, 2023 - mdpi.com
The coronavirus disease 2019 (COVID-19) pandemic has led to changes in lifestyle, which
could influence vitamin D status on a population level. The purpose of our study was to …

[HTML][HTML] Liposome encapsulated clodronate mediated elimination of pathogenic macrophages and microglia: A promising pharmacological regime to defuse cytokine …

S Ravichandran, N Manickam, M Kandasamy - Medicine in Drug Discovery, 2022 - Elsevier
The emergence of new SARS-CoV-2 variants continues to pose an enormous public health
concern. The SARS-CoV-2 infection disrupted host immune response accounting for …

[HTML][HTML] Overreactive macrophages in SARS-CoV-2 infection: The effects of ACEI

D Felkle, K Zięba, K Kaleta, J Czaja, A Zyzdorf… - International …, 2023 - Elsevier
Among various factors influencing the course of SARS-CoV-2 infection in humans,
macrophage overactivation is considered the main cause of the cytokine storm that leads to …

[HTML][HTML] Intravenous IgM-enriched immunoglobulins in critical COVID-19: a multicentre propensity-weighted cohort study

T Rahmel, F Kraft, H Haberl, U Achtzehn… - Critical Care, 2022 - Springer
Background A profound inflammation-mediated lung injury with long-term acute respiratory
distress and high mortality is one of the major complications of critical COVID-19 …

[HTML][HTML] Age related differences in monocyte subsets and cytokine pattern during acute COVID-19—A prospective observational longitudinal study

A Pirabe, S Heber, WC Schrottmaier… - Cells, 2021 - mdpi.com
The COVID-19 pandemic drastically highlighted the vulnerability of the elderly population
towards viral and other infectious threats, illustrating that aging is accompanied by …

[HTML][HTML] COVID-19 pandemic: A multidisciplinary perspective on the pathogenesis of a novel coronavirus from infection, immunity and pathological responses

J Yi, J Miao, Q Zuo, F Owusu, Q Dong, P Lin… - Frontiers in …, 2022 - frontiersin.org
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome
coronavirus2 (SARS-CoV-2), has spread to more than 200 countries and regions, having a …

[HTML][HTML] Glucosinolates and their hydrolysis products as potential nutraceuticals to combat cytokine storm in SARS-COV-2

SR Bahoosh, Y Shokoohinia, M Eftekhari - DARU Journal of …, 2022 - Springer
Introduction The high mortality rate in severe cases of COVID-19 is mainly due to the strong
upregulation of cytokines, called a cytokine storm. Hyperinflammation and multiple organ …