Sickle cell disease: advances in treatment
RV Gardner - Ochsner journal, 2018 - ochsnerjournal.org
Background: Sickle cell disease causes significant morbidity and mortality and affects the
economic and healthcare status of many countries. Yet historically, the disease has not had …
economic and healthcare status of many countries. Yet historically, the disease has not had …
[HTML][HTML] Understanding apoptosis in sickle cell anemia patients: Mechanisms and implications
Sickle cell anemia (SCA) is a hereditary blood disorder characterized by the presence of
abnormal hemoglobin, leading to the formation of sickle-shaped red blood cells. While much …
abnormal hemoglobin, leading to the formation of sickle-shaped red blood cells. While much …
Neutrophil adhesion in brain capillaries reduces cortical blood flow and impairs memory function in Alzheimer's disease mouse models
JC Cruz Hernández, O Bracko, CJ Kersbergen… - Nature …, 2019 - nature.com
Cerebral blood flow (CBF) reductions in Alzheimer's disease patients and related mouse
models have been recognized for decades, but the underlying mechanisms and resulting …
models have been recognized for decades, but the underlying mechanisms and resulting …
Microfluidic study of retention and elimination of abnormal red blood cells by human spleen with implications for sickle cell disease
The spleen clears altered red blood cells (RBCs) from circulation, contributing to the balance
between RBC formation (erythropoiesis) and removal. The splenic RBC retention and …
between RBC formation (erythropoiesis) and removal. The splenic RBC retention and …
Kinetics and mechanics of clot contraction are governed by the molecular and cellular composition of the blood
Platelet-driven blood clot contraction (retraction) is thought to promote wound closure and
secure hemostasis while preventing vascular occlusion. Notwithstanding its importance, clot …
secure hemostasis while preventing vascular occlusion. Notwithstanding its importance, clot …
The key role of GSH in keeping the redox balance in mammalian cells: mechanisms and significance of GSH in detoxification via formation of conjugates
SK Georgiou-Siafis, AS Tsiftsoglou - Antioxidants, 2023 - mdpi.com
Glutathione (GSH) is a ubiquitous tripeptide that is biosynthesized in situ at high
concentrations (1–5 mM) and involved in the regulation of cellular homeostasis via multiple …
concentrations (1–5 mM) and involved in the regulation of cellular homeostasis via multiple …
Whole blood viscosity and red blood cell adhesion: Potential biomarkers for targeted and curative therapies in sickle cell disease
Sickle cell disease (SCD) is a recessive genetic blood disorder exhibiting abnormal blood
rheology. Polymerization of sickle hemoglobin, due to a point mutation in the β‐globin gene …
rheology. Polymerization of sickle hemoglobin, due to a point mutation in the β‐globin gene …
Computer-aided classification of sickle cell retinopathy using quantitative features in optical coherence tomography angiography
As a new optical coherence tomography (OCT) imaging modality, there is no standardized
quantitative interpretation of OCT angiography (OCTA) characteristics of sickle cell …
quantitative interpretation of OCT angiography (OCTA) characteristics of sickle cell …
Characterization of red blood cell microcirculatory parameters using a bioimpedance microfluidic device
This paper describes the use of a microfluidic device comprising channels with dimensions
mimicking those of the smallest capillaries found in the human microcirculation. The device …
mimicking those of the smallest capillaries found in the human microcirculation. The device …
Gender-related differences in sickle cell disease in a pediatric cohort: a single-center retrospective study
G Ceglie, M Di Mauro, I Tarissi De Jacobis… - Frontiers in Molecular …, 2019 - frontiersin.org
Sickle cell disease (SCD) is one of the most common monogenic disease worldwide. The
incidence of SCD is not strictly gender-related as it is transmitted as an autosomal recessive …
incidence of SCD is not strictly gender-related as it is transmitted as an autosomal recessive …