Recent advances in genomics have revealed a wide spectrum of genetic variants
associated with neurodevelopmental disorders at an unprecedented scale. An increasing …

Substance use in adolescence is a known risk factor for the development of neuropsychiatric
and substance use disorders in adulthood. This is in part due to the fact that critical aspects …

Initiating drug use during adolescence increases the risk of developing addiction or other
psychopathologies later in life, with long-term outcomes varying according to sex and exact …

The prefrontal cortex plays a central role in the control of complex cognitive processes
including action control and decision making. It also shows a specific pattern of delayed …

Neuropsychiatric symptoms (NPS) occur in nearly all patients with Alzheimer's Disease
(AD). Most frequently they appear since the mild cognitive impairment (MCI) stage preceding …

It is hard to overestimate the influence of the endocannabinoid signaling (ECS) system on
central nervous system (CNS) function. In the 40 years since cannabinoids were found to …

Anhedonia, or diminished pleasure and motivation, is a symptom of severe mental illness
(eg, depressive disorder, bipolar disorder, schizophrenia) that emerges during adolescence …

In this review, we focus on prenatal opioid exposure (POE) given the significant concern for
the mental health outcomes of children with parents affected by opioid use disorder (OUD) in …

Inhibitory control can be less reliable in adolescence, however, in the presence of rewards,
adolescents' performance often improves to adult levels. Dopamine is known to play a role …

Age-related alterations in D1-like dopamine receptor (D1DR) have distinct implications for
human cognition and behavior during development and aging, but the timing of these …