Using autopsies to dissect COVID-19 pathogenesis

F Heinrich, KD Mertz, M Glatzel, M Beer… - Nature …, 2023 - nature.com
The emergence of SARS-CoV-2 has resulted in millions of deaths as a result of COVID-19.
Suitable models were missing at the beginning of the pandemic, and studies investigating …

Immunomodulatory fecal metabolites are associated with mortality in COVID-19 patients with respiratory failure

MR Stutz, NP Dylla, SD Pearson… - Nature …, 2022 - nature.com
Respiratory failure and mortality from COVID-19 result from virus-and inflammation-induced
lung tissue damage. The intestinal microbiome and associated metabolites are implicated in …

Divergent adaptive immune responses define two types of long COVID

J Kervevan, I Staropoli, D Slama… - Frontiers in …, 2023 - frontiersin.org
Background The role of adaptive immune responses in long COVID remains poorly
understood, with contrasting hypotheses suggesting either an insufficient antiviral response …

Viable SARS-CoV-2 Omicron sub-variants isolated from autopsy tissues

S Maffia-Bizzozero, C Cevallos, FR Lenicov… - Frontiers in …, 2023 - frontiersin.org
Introduction Pulmonary and extrapulmonary manifestations have been described after
infection with SARS-CoV-2, the causative agent of coronavirus disease 2019 (COVID-19) …

Research autopsy programmes in oncology: shared experience from 14 centres across the world

T Geukens, M Maetens, JE Hooper… - The Journal of …, 2024 - Wiley Online Library
While there is a great clinical need to understand the biology of metastatic cancer in order to
treat it more effectively, research is hampered by limited sample availability. Research …

Organ-specific immunity: A tissue analysis framework for investigating local immune responses to SARS-CoV-2

AHC Ng, H Hu, K Wang, K Scherler, SE Warren… - Cell Reports, 2023 - cell.com
Local immune activation at mucosal surfaces, mediated by mucosal lymphoid tissues, is vital
for effective immune responses against pathogens. While pathogens like severe acute …

[HTML][HTML] The need for integrated research autopsies in the era of precision oral medicine

BF Matuck, LFF da Silva, BM Warner… - The Journal of the …, 2023 - Elsevier
Background Autopsy has benefited the practice of medicine for centuries; however, its use to
advance the practice of oral health care is relatively limited. In the era of precision oral …

Host and microbiome features of secondary infections in lethal covid-19

M Zacharias, K Kashofer, P Wurm, P Regitnig… - IScience, 2022 - cell.com
Secondary infections contribute significantly to covid-19 mortality but driving factors remain
poorly understood. Autopsies of 20 covid-19 cases and 14 controls from the first pandemic …

Profibrotic COVID-19 subphenotype exhibits enhanced localized ER-dependent HSP47+ expression in cardiac myofibroblasts in situ

ER Jacobs, GR Ross, N Padilla, AY Pan, M Liegl… - Journal of Molecular and …, 2023 - Elsevier
We recently described a subgroup of autopsied COVID-19 subjects (∼ 40%), termed
'profibrotic phenotype,'who exhibited clusters of myofibroblasts (Mfbs), which were positive …

Neurolinguistic deficits and other cognitive disorders in adults with severe COVID-19 infection

K Priftis - COVID-19 and speech-language pathology, 2022 - api.taylorfrancis.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and the resulting
coronavirus disease 2019 (COVID-19) has caused a pandemic. At the time of writing, more …