Ensemble deep learning in bioinformatics

Y Cao, TA Geddes, JYH Yang, P Yang - Nature Machine Intelligence, 2020 - nature.com
The remarkable flexibility and adaptability of ensemble methods and deep learning models
have led to the proliferation of their application in bioinformatics research. Traditionally …

[HTML][HTML] Autism spectrum heterogeneity: fact or artifact?

L Mottron, D Bzdok - Molecular psychiatry, 2020 - nature.com
The current diagnostic practices are linked to a 20-fold increase in the reported prevalence
of ASD over the last 30 years. Fragmenting the autism phenotype into dimensional “autistic …

[HTML][HTML] Different scaling of linear models and deep learning in UKBiobank brain images versus machine-learning datasets

MA Schulz, BTT Yeo, JT Vogelstein… - Nature …, 2020 - nature.com
Recently, deep learning has unlocked unprecedented success in various domains,
especially using images, text, and speech. However, deep learning is only beneficial if the …

Precision medicine in stroke: towards personalized outcome predictions using artificial intelligence

AK Bonkhoff, C Grefkes - Brain, 2022 - academic.oup.com
Stroke ranks among the leading causes for morbidity and mortality worldwide. New and
continuously improving treatment options such as thrombolysis and thrombectomy have …

[HTML][HTML] Finding the needle in a high-dimensional haystack: Canonical correlation analysis for neuroscientists

HT Wang, J Smallwood, J Mourao-Miranda, CH Xia… - NeuroImage, 2020 - Elsevier
The 21st century marks the emergence of “big data” with a rapid increase in the availability
of datasets with multiple measurements. In neuroscience, brain-imaging datasets are more …

[HTML][HTML] Functional specialization within the inferior parietal lobes across cognitive domains

O Numssen, D Bzdok, G Hartwigsen - elife, 2021 - elifesciences.org
The inferior parietal lobe (IPL) is a key neural substrate underlying diverse mental
processes, from basic attention to language and social cognition, that define human …

Prediction, not association, paves the road to precision medicine

D Bzdok, G Varoquaux, EW Steyerberg - JAMA psychiatry, 2021 - jamanetwork.com
In the 20th century, evidence-based medicine has put clinical practice on much more solid
ground. For instance, randomized clinical trials have provided strong evidence on useful …

[HTML][HTML] Canonical correlation analysis and partial least squares for identifying brain–behavior associations: A tutorial and a comparative study

A Mihalik, J Chapman, RA Adams, NR Winter… - Biological Psychiatry …, 2022 - Elsevier
Canonical correlation analysis (CCA) and partial least squares (PLS) are powerful
multivariate methods for capturing associations across 2 modalities of data (eg, brain and …

Trips and neurotransmitters: Discovering principled patterns across 6850 hallucinogenic experiences

G Ballentine, SF Friedman, D Bzdok - Science advances, 2022 - science.org
Psychedelics probably alter states of consciousness by disrupting how the higher
association cortex governs bottom-up sensory signals. Individual hallucinogenic drugs are …

The social nature of mitochondria: Implications for human health

M Picard, C Sandi - Neuroscience & Biobehavioral Reviews, 2021 - Elsevier
Sociality has profound evolutionary roots and is observed from unicellular organisms to
multicellular animals. In line with the view that social principles apply across levels of …