The joint analysis of the genome, epigenome, transcriptome, proteome and/or metabolome
from single cells is transforming our understanding of cell biology in health and disease. In …

Single-cell transcriptomic approaches have revolutionised the study of complex biological
systems, with the routine measurement of gene expression in thousands of cells enabling …

Human oocytes are prone to assembling meiotic spindles with unstable poles, which can
favor aneuploidy in human eggs. The underlying causes of spindle instability are unknown …

Abstract In mammals, DNA 5-hydroxymethylcytosine (5hmC) is involved in methylation
reprogramming during early embryonic development. Yet, to what extent 5hmC participates …

Bulk sequencing methodologies have allowed us to make great progress in cancer
research. Unfortunately, these techniques lack the resolution to fully unravel the epigenetic …

In recent years, more and more single-cell technologies have been developed. A vast
amount of single-cell omics data has been generated by large projects, such as the Human …

Human spermatogenesis is a highly ordered process; however, the roles of DNA
methylation and chromatin accessibility in this process remain largely unknown. Here by …

Neural tube (NT) defects arise from abnormal neurulation and result in the most common
birth defects worldwide. Yet, mechanisms of primate neurulation remain largely unknown …

Inducing lysosomal dysfunction is emerging as a promising means for cancer therapy.
Agrocybe cylindracea fucoglucogalactan (ACP) is a bioactive ingredient with anti-tumor …

Disseminated intravascular coagulation (DIC) is a complication of sepsis currently lacking
effective therapeutic options. Excessive inflammatory responses are emerging triggers of …