An update on drugs with therapeutic potential for SARS-CoV-2 (COVID-19) treatment

S Drożdżal, J Rosik, K Lechowicz, F Machaj… - Drug Resistance …, 2021 - Elsevier
The COVID-19 pandemic is one of the greatest threats to human health in the 21st century
with more than 257 million cases and over 5.17 million deaths reported worldwide (as of …

Long-COVID and post-COVID health complications: an up-to-date review on clinical conditions and their possible molecular mechanisms

B Silva Andrade, S Siqueira, WR de Assis Soares… - Viruses, 2021 - mdpi.com
The COVID-19 pandemic has infected millions worldwide, leaving a global burden for long-
term care of COVID-19 survivors. It is thus imperative to study post-COVID (ie, short-term) …

Pathogenic mechanisms of post-acute sequelae of SARS-CoV-2 infection (PASC)

ZA Sherif, CR Gomez, TJ Connors, TJ Henrich… - Elife, 2023 - elifesciences.org
COVID-19, with persistent and new onset of symptoms such as fatigue, post-exertional
malaise, and cognitive dysfunction that last for months and impact everyday functioning, is …

Prolonged elevation of D‐dimer levels in convalescent COVID‐19 patients is independent of the acute phase response

L Townsend, H Fogarty, A Dyer… - … of Thrombosis and …, 2021 - Wiley Online Library
Background Persistent fatigue, breathlessness, and reduced exercise tolerance have been
reported following acute COVID‐19 infection. Although immuno‐thrombosis has been …

Symptom persistence despite improvement in cardiopulmonary health–insights from longitudinal CMR, CPET and lung function testing post-COVID-19

MP Cassar, EM Tunnicliffe, N Petousi… - …, 2021 - thelancet.com
Background The longitudinal trajectories of cardiopulmonary abnormalities and symptoms
following infection with coronavirus disease (COVID-19) are unclear. We sought to describe …

The pathogenesis and long-term consequences of COVID-19 cardiac injury

B Siripanthong, B Asatryan, TC Hanff… - Basic to Translational …, 2022 - jacc.org
The mechanisms of coronavirus disease-2019 (COVID-19)–related myocardial injury
comprise both direct viral invasion and indirect (hypercoagulability and immune-mediated) …

Intensive care management of patients with COVID-19: a practical approach

LA Hajjar, IBSS Costa, SI Rizk, B Biselli… - Annals of Intensive …, 2021 - Springer
Abstract SARS-CoV-2, the causative agent of coronavirus disease 2019 (COVID-19), is
responsible for the largest pandemic facing humanity since the Spanish flu pandemic in the …

Impact of heart failure on the clinical course and outcomes of patients hospitalized for COVID‐19. Results of the Cardio‐COVID‐Italy multicentre study

D Tomasoni, RM Inciardi, CM Lombardi… - European journal of …, 2020 - Wiley Online Library
Aims To assess the prognostic value of a history of heart failure (HF) in patients with
coronavirus disease 2019 (COVID‐19). Methods and results We enrolled 692 consecutive …

The potential role of ischaemia–reperfusion injury in chronic, relapsing diseases such as rheumatoid arthritis, Long COVID, and ME/CFS: evidence, mechanisms, and …

DB Kell, E Pretorius - Biochemical Journal, 2022 - portlandpress.com
Ischaemia–reperfusion (I–R) injury, initiated via bursts of reactive oxygen species produced
during the reoxygenation phase following hypoxia, is well known in a variety of acute …

[HTML][HTML] COVID-19 and the heart: a systematic review of cardiac autopsies

A Roshdy, S Zaher, H Fayed… - Frontiers in cardiovascular …, 2021 - frontiersin.org
Importance: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-associated
cardiac injury has been postulated secondary to several mechanisms. While tissue …