Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases that
affect millions of people worldwide, with both prevalence and incidence increasing with age …

Aging represents the single greatest risk factor for chronic diseases, including osteoporosis,
a skeletal fragility syndrome that increases fracture risk. Optimizing bone strength throughout …

Skin aging is associated with the accumulation of senescent cells and is related to many
pathological changes, including decreased protection against pathogens, increased …

Age-related chronic diseases are an enormous burden to modern societies worldwide.
Among these, osteoporosis, a condition that predisposes individuals to an increased risk of …

Progressive loss of physiological integrity and accumulation of degenerative changes
leading to functional impairment and increased susceptibility to diseases are the main …

Despite the growing interest by researchers into cellular senescence, a hallmark of cellular
aging, its role in human skin remains equivocal. The skin is the largest and most accessible …

Intervertebral disc degeneration (IDD) is a common degenerative musculoskeletal disorder
and is recognized as a major contributor to discogenic lower back pain. However, the …

The process of cellular senescence is rapidly emerging as a modulator of organismal aging
and disease. Targeting the development and removal of senescent cells is considered a …

Cancer progression is supported by the cross-talk between tumor cells and the surrounding
stroma. In this context, senescent cells in the tumor microenvironment contribute to the …

Cellular senescence generates a permanent cell cycle arrest, characterized by apoptosis
resistance and a pro-inflammatory senescence-associated secretory phenotype (SASP) …