Prevention and attenuation of Covid-19 with the BNT162b2 and mRNA-1273 vaccines
MG Thompson, JL Burgess, AL Naleway… - … England Journal of …, 2021 - Mass Medical Soc
Background Information is limited regarding the effectiveness of the two-dose messenger
RNA (mRNA) vaccines BNT162b2 (Pfizer–BioNTech) and mRNA-1273 (Moderna) in …
RNA (mRNA) vaccines BNT162b2 (Pfizer–BioNTech) and mRNA-1273 (Moderna) in …
[HTML][HTML] Engineering circular RNA for enhanced protein production
Circular RNAs (circRNAs) are stable and prevalent RNAs in eukaryotic cells that arise from
back-splicing. Synthetic circRNAs and some endogenous circRNAs can encode proteins …
back-splicing. Synthetic circRNAs and some endogenous circRNAs can encode proteins …
SARS-CoV-2 variants of concern partially escape humoral but not T cell responses in COVID-19 convalescent donors and vaccine recipients
D Geers, MC Shamier, S Bogers, G den Hartog… - Science …, 2021 - science.org
The emergence of SARS-CoV-2 variants harboring mutations in the spike (S) protein has
raised concern about potential immune escape. Here, we studied humoral and cellular …
raised concern about potential immune escape. Here, we studied humoral and cellular …
[HTML][HTML] mRNA-1273 COVID-19 vaccine effectiveness against the B. 1.1. 7 and B. 1.351 variants and severe COVID-19 disease in Qatar
The SARS-CoV-2 pandemic continues to be a global health concern. The mRNA-1273
(Moderna) vaccine was reported to have an efficacy of 94.1% at preventing symptomatic …
(Moderna) vaccine was reported to have an efficacy of 94.1% at preventing symptomatic …
Durability of mRNA-1273 vaccine–induced antibodies against SARS-CoV-2 variants
A Pegu, SE O'Connell, SD Schmidt, S O'Dell… - Science, 2021 - science.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mutations may diminish
vaccine-induced protective immune responses, particularly as antibody titers wane over …
vaccine-induced protective immune responses, particularly as antibody titers wane over …
Nanotechnology-based mRNA vaccines
Abstract mRNA vaccines have emerged as a revolutionary tool to generate rapid and
precise immune responses against infectious diseases and cancers. Compared with …
precise immune responses against infectious diseases and cancers. Compared with …
[HTML][HTML] Translational advances in pancreatic ductal adenocarcinoma therapy
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer that is most frequently
detected at advanced stages, limiting treatment options to systemic chemotherapy with …
detected at advanced stages, limiting treatment options to systemic chemotherapy with …
[HTML][HTML] The humoral response and antibodies against SARS-CoV-2 infection
Two and a half years into the COVID-19 pandemic, we have gained many insights into the
human antibody response to the causative SARS-CoV-2 virus. In this Review, we …
human antibody response to the causative SARS-CoV-2 virus. In this Review, we …
Three waves changes, new variant strains, and vaccination effect against COVID-19 pandemic
It has been more than one year since the first case of the coronaviruses was infected by
COVID-19 in China. The world witnessed three waves of the corona virus till now, and more …
COVID-19 in China. The world witnessed three waves of the corona virus till now, and more …
[HTML][HTML] mRNA-lipid nanoparticle COVID-19 vaccines: Structure and stability
A drawback of the current mRNA-lipid nanoparticle (LNP) COVID-19 vaccines is that they
have to be stored at (ultra) low temperatures. Understanding the root cause of the instability …
have to be stored at (ultra) low temperatures. Understanding the root cause of the instability …