[HTML][HTML] Therapeutic strategies for COVID-19: progress and lessons learned

G Li, R Hilgenfeld, R Whitley, E De Clercq - Nature Reviews Drug …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …

Monoclonal antibody therapies against SARS-CoV-2

D Focosi, S McConnell, A Casadevall… - The Lancet Infectious …, 2022 - thelancet.com
Monoclonal antibodies (mAbs) targeting the spike protein of SARS-CoV-2 have been widely
used in the ongoing COVID-19 pandemic. In this paper, we review the properties of mAbs …

Omicron BA. 2 (B. 1.1. 529.2): high potential for becoming the next dominant variant

J Chen, GW Wei - The journal of physical chemistry letters, 2022 - ACS Publications
The Omicron variant has three subvariants: BA. 1 (B. 1.1. 529.1), BA. 2 (B. 1.1. 529.2), and
BA. 3 (B. 1.1. 529.3). BA. 2 is found to be able to alarmingly reinfect patients originally …

Structural insights for neutralization of Omicron variants BA. 1, BA. 2, BA. 4, and BA. 5 by a broadly neutralizing SARS-CoV-2 antibody

S Kumar, A Patel, L Lai, C Chakravarthy… - Science …, 2022 - science.org
In this study, by characterizing several human monoclonal antibodies (mAbs) isolated from
single B cells of the COVID-19–recovered individuals in India who experienced ancestral …

Structure-based neutralizing mechanisms for SARS-CoV-2 antibodies

Q Huang, X Han, J Yan - Emerging Microbes & Infections, 2022 - Taylor & Francis
The devastating economic and public health consequences caused by the COVID-19
pandemic have prompted outstanding efforts from the scientific community and …

[HTML][HTML] COVID-19 in patients with anemia and haematological malignancies: risk factors, clinical guidelines, and emerging therapeutic approaches

S Kakavandi, B Hajikhani, P Azizi, F Aziziyan… - Cell Communication and …, 2024 - Springer
Extensive research in countries with high sociodemographic indices (SDIs) to date has
shown that coronavirus disease 2019 (COVID-19) may be directly associated with more …

[HTML][HTML] A Spike-destructing human antibody effectively neutralizes Omicron-included SARS-CoV-2 variants with therapeutic efficacy

L Meng, J Zha, B Zhou, L Cao, C Jiang, Y Zhu… - PLoS …, 2023 - journals.plos.org
Neutralizing antibodies (nAbs) are important assets to fight COVID-19, but most existing
nAbs lose the activities against Omicron subvariants. Here, we report a human monoclonal …

[HTML][HTML] Hetero-bivalent nanobodies provide broad-spectrum protection against SARS-CoV-2 variants of concern including Omicron

H Ma, X Zhang, P Zheng, PH Dube, W Zeng, S Chen… - Cell Research, 2022 - nature.com
SARS-CoV-2 variants with adaptive mutations have continued to emerge, causing fresh
waves of infection even amongst vaccinated population. The development of broad …

[HTML][HTML] Mechanism of a rabbit monoclonal antibody broadly neutralizing SARS-CoV-2 variants

H Guo, Y Yang, T Zhao, Y Lu, Y Gao, T Li… - Communications …, 2023 - nature.com
Due to the continuous evolution of SARS-CoV-2, the Omicron variant has emerged and
exhibits severe immune evasion. The high number of mutations at key antigenic sites on the …

[HTML][HTML] A broadly neutralizing monoclonal antibody overcomes the mutational landscape of emerging SARS-CoV-2 variants of concern

HA Parray, N Narayanan, S Garg, ZA Rizvi… - PLoS …, 2022 - journals.plos.org
The emergence of new variants of SARS-CoV-2 necessitates unremitting efforts to discover
novel therapeutic monoclonal antibodies (mAbs). Here, we report an extremely potent mAb …