Recent human genetic studies have linked a variety of genetic variants in the CACNA1C
and CACNA1D genes to neuropsychiatric and neurodevelopmental disorders. This is not …

Drug development is a long and costly process, with a high degree of uncertainty from the
identification of a drug target to its market launch. Targeted drugs supported by human …

Objective Due to the phenotypic heterogeneity and etiological complexity of bipolar disorder
(BD), many patients do not respond well to the current medications, and developing novel …

Bipolar disorder (BD) is a severe psychiatric illness characterized by recurrent episodes of
mania/hypomania and depression. Based on the investigations into the pathological and …

Background Schizophrenia and bipolar disorder (BD) are believed to share clinical
symptoms, genetic risk, etiological factors, and pathogenic mechanisms. We previously …

Background Bipolar disorder (BD) is a highly burdensome psychiatric disorder characterized
by alternating states of mania and depression. A major challenge in the clinic is the switch …

Background This study analyzed the extent to which irregularities in genetic diversity
separate psychiatric patients from healthy controls. Methods Genetic diversity was quantified …

Background Growing evidence suggests the presence of white matter (WM) alterations in
bipolar disorder (BD). In this study we aimed to investigate the state of WM structures, in …

Lithium (Li) is the first-line treatment for bipolar disorder (BD) even though only 30% of BD
patients are considered excellent responders. The mechanisms by which Li exerts its action …

Bipolar disorder (BD) is a heritable psychiatric disorder with a complex etiology that is often
associated with cortical alterations. Morphometric studies in adults with BD are well …