Genome-wide association meta-analysis of spontaneous coronary artery dissection identifies risk variants and genes related to artery integrity and tissue-mediated …
Spontaneous coronary artery dissection (SCAD) is an understudied cause of myocardial
infarction primarily affecting women. It is not known to what extent SCAD is genetically …
infarction primarily affecting women. It is not known to what extent SCAD is genetically …
The genetic basis of major depressive disorder
J Flint - Molecular psychiatry, 2023 - nature.com
The genetic dissection of major depressive disorder (MDD) ranks as one of the success
stories of psychiatric genetics, with genome-wide association studies (GWAS) identifying …
stories of psychiatric genetics, with genome-wide association studies (GWAS) identifying …
Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences
Humans vary substantially in their willingness to take risks. In a combined sample of over 1
million individuals, we conducted genome-wide association studies (GWAS) of general risk …
million individuals, we conducted genome-wide association studies (GWAS) of general risk …
Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility
Brugada syndrome (BrS) is a cardiac arrhythmia disorder associated with sudden death in
young adults. With the exception of SCN5A, encoding the cardiac sodium channel NaV1. 5 …
young adults. With the exception of SCN5A, encoding the cardiac sodium channel NaV1. 5 …
Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types
We introduce an approach to identify disease-relevant tissues and cell types by analyzing
gene expression data together with genome-wide association study (GWAS) summary …
gene expression data together with genome-wide association study (GWAS) summary …
Brain proteome-wide association study implicates novel proteins in depression pathogenesis
TS Wingo, Y Liu, ES Gerasimov, J Gockley… - Nature …, 2021 - nature.com
Depression is a common condition, but current treatments are only effective in a subset of
individuals. To identify new treatment targets, we integrated depression genome-wide …
individuals. To identify new treatment targets, we integrated depression genome-wide …
Multi-ancestry genome-wide association study of cannabis use disorder yields insight into disease biology and public health implications
As recreational use of cannabis is being decriminalized in many places and medical use
widely sanctioned, there are growing concerns about increases in cannabis use disorder …
widely sanctioned, there are growing concerns about increases in cannabis use disorder …
[PDF][PDF] Constrained maximum likelihood-based Mendelian randomization robust to both correlated and uncorrelated pleiotropic effects
With the increasing availability of large-scale GWAS summary data on various complex traits
and diseases, there have been tremendous interests in applications of Mendelian …
and diseases, there have been tremendous interests in applications of Mendelian …
Analysis of cardiac magnetic resonance imaging in 36,000 individuals yields genetic insights into dilated cardiomyopathy
Dilated cardiomyopathy (DCM) is an important cause of heart failure and the leading
indication for heart transplantation. Many rare genetic variants have been associated with …
indication for heart transplantation. Many rare genetic variants have been associated with …
Trans-ethnic association study of blood pressure determinants in over 750,000 individuals
In this trans-ethnic multi-omic study, we reinterpret the genetic architecture of blood pressure
to identify genes, tissues, phenomes and medication contexts of blood pressure …
to identify genes, tissues, phenomes and medication contexts of blood pressure …