We discuss some of the practical challenges that one faces in using stochastic
thermodynamics to infer directionality of molecular machines from experimental single …

Single-molecule spectroscopy is a powerful method for studying the physics of molecular
systems, particularly biomolecules, such as proteins and nucleic acids. By avoiding …

Many nonequilibrium, active processes are observed at a coarse-grained level, where
different microscopic configurations are projected onto the same observable state. Such …

Rate-dependent fracture has been observed for a silicon/epoxy interface as well as other
polymer interfaces, where both the interfacial strength and toughness increase with the …

Coupling of mechanical forces and chemical transformations is central to the biophysics of
molecular machines, polymer chemistry, fracture mechanics, tribology, and other disciplines …

Recent single-molecule experiments have observed transition paths, ie, brief events where
molecules (particularly biomolecules) are caught in the act of surmounting activation …

Atomically detailed computer simulations of complex molecular events attracted the
imagination of many researchers in the field as providing comprehensive information on …

ABSTRACT “Gating” is a widely observed phenomenon in biochemistry that describes the
transition between the activated (or open) and deactivated (or closed) states of an ion …

Conformational memory in single-molecule dynamics has attracted recent attention and, in
particular, has been invoked as a possible explanation of some of the intriguing properties of …

Recent single-molecule experiments probed transition paths of biomolecular folding and, in
particular, measured the time biomolecules spend while crossing their free energy barriers …