Great progress has been made in recent years to reduce the high level of suffering caused
by malaria worldwide. Notably, the use of insecticide-treated mosquito nets for malaria …

The global adoption of artemisinin-based combination therapies (ACTs) in the early 2000s
heralded a new era in effectively treating drug-resistant Plasmodium falciparum malaria …

At present, the legendary magic bullet, ie, a drug with high potency and selectivity toward a
specific biological target, shares the spotlight with an emerging and alternative …

The emergence of mutant K13-mediated artemisinin (ART) resistance in Plasmodium
falciparum malaria parasites has led to widespread treatment failures across Southeast …

The worldwide use of artemisinin-based combination therapies (ACTs) has contributed in
recent years to a substantial reduction in deaths resulting from Plasmodium falciparum …

The emergence of artemisinin resistance in Southeast Asia imperils efforts to reduce the
global malaria burden. We genetically modified the Plasmodium falciparum K13 locus using …

The widely used antimalarial combination therapy dihydroartemisinin+ piperaquine (DHA+
PPQ) has failed in Cambodia. Here, we perform a genomic analysis that reveals a rapid …

Recent reports of increased tolerance to artemisinin derivatives—the most recently adopted
class of antimalarials—have prompted a need for new treatments. The spirotetrahydro-β …

Antimalarial drug resistance has historically arisen through convergent de novo mutations in
Plasmodium falciparum parasite populations in Southeast Asia and South America. For the …

Approximately 10% of antimicrobials used by humans in low-and middle-income countries
are estimated to be substandard or falsified. In addition to their negative impact on morbidity …