Computational approaches for network-based integrative multi-omics analysis

FE Agamah, JR Bayjanov, A Niehues… - Frontiers in Molecular …, 2022 - frontiersin.org
Advances in omics technologies allow for holistic studies into biological systems. These
studies rely on integrative data analysis techniques to obtain a comprehensive view of the …

[HTML][HTML] Mechanism and potential treatments for gastrointestinal dysfunction in patients with COVID-19

Y Yao, ZJ Liu, YK Zhang, HJ Sun - World Journal of …, 2022 - ncbi.nlm.nih.gov
The global coronavirus disease 2019 (COVID-19) has become one of the biggest threats to
the world since 2019. The respiratory and gastrointestinal tracts are the main targets for …

Significance of nitrosative stress and glycoxidation products in the diagnosis of COVID-19

B Wolszczak-Biedrzycka, J Dorf, J Matowicka-Karna… - Scientific Reports, 2024 - nature.com
Nitrosative stress promotes protein glycoxidation, and both processes can occur during an
infection with the SARS-CoV-2 virus. Therefore, the aim of this study was to assess selected …

Growth differentiation factor 15 (GDF-15) levels associate with lower survival in chronic kidney disease patients with COVID-19

A Galassi, P Ciceri, V Bono, L Magagnoli, M Sala… - Biomedicines, 2022 - mdpi.com
A cytokine storm drives the pathogenesis of severe COVID-19 infection and several
biomarkers have been linked to mortality. Chronic kidney disease (CKD) emerged as a risk …

Integrative Molecular Structure Elucidation and Construction of an Extended Metabolic Pathway Associated with an Ancient Innate Immune Response in COVID-19 …

S Sala, P Nitschke, R Masuda, N Gray… - Journal of proteome …, 2024 - ACS Publications
We present compelling evidence for the existence of an extended innate viperin-dependent
pathway, which provides crucial evidence for an adaptive response to viral agents, such as …

The metaproteome of the gut microbiota in pediatric patients affected by COVID-19

V Marzano, SL Mortera, C Marangelo… - Frontiers in Cellular …, 2023 - frontiersin.org
Introduction The gut microbiota (GM) play a significant role in the infectivity and severity of
COVID-19 infection. However, the available literature primarily focuses on adult patients and …

Potential Beneficial Effects of Naringin and Naringenin on Long COVID—A Review of the Literature

S Liu, M Zhong, H Wu, W Su, Y Wang, P Li - Microorganisms, 2024 - mdpi.com
Coronavirus disease 2019 (COVID-19) caused a severe epidemic due to severe acute
respiratory syndrome coronavirus-2 (SARS-CoV-2). Recent studies have found that patients …

Developing A Baseline Metabolomic Signature Associated with COVID-19 Severity: Insights from Prospective Trials Encompassing 13 US Centers

K Yang, Z Kang, W Guan, S Lotfi-Emran, ZJ Mayer… - Metabolites, 2023 - mdpi.com
Metabolic disease is a significant risk factor for severe COVID-19 infection, but the
contributing pathways are not yet fully elucidated. Using data from two randomized …

Amino Acid Metabolism in Leukocytes Showing In Vitro IgG Memory from SARS-CoV2-Infected Patients

G Fanelli, V Lelli, S Rinalducci, AM Timperio - Diseases, 2024 - mdpi.com
The immune response to infectious diseases is directly influenced by metabolic activities.
COVID-19 is a disease that affects the entire body and can significantly impact cellular …

SARS-CoV-2 infection biomarkers reveal an extended RSAD2 dependant metabolic pathway

S Sala, P Nitschke, R Masuda, N Gray, N Lawler… - MedRxiv, 2023 - medrxiv.org
We present compelling evidence for the existence of an extended innate viperin dependent
pathway which provides crucial evidence for an adaptive response to viral agents like SARS …