Aging, as a complex process involving multiple cellular and molecular pathways, is known to
be exacerbated by various stresses. Because responses to these stresses, such as oxidative …

Epigenetic dysregulation emerges as a critical hallmark and driving force of aging. Although
still an evolving field with much to explore, it has rapidly gained significance by providing …

Aging is a major risk factor contributing to pathophysiological changes in the heart, yet its
intrinsic mechanisms have been largely unexplored in primates. In this study, we …

Our understanding of the molecular basis for cellular senescence remains incomplete,
limiting the development of strategies to ameliorate age-related pathologies by preventing …

Regeneration across tissues and organs exhibits significant variation throughout the body
and undergoes a progressive decline with age. To decode the relationships between aging …

Aging of the vasculature, which is integral to the functioning of literally all human organs,
serves as a fundamental physiological basis for age-related alterations as well as a shared …

Alzheimer's disease (AD) is a neurodegenerative disorder that affects millions worldwide
and is expected to surge in prevalence due to aging populations. Frailty, characterized by …

The theory that oxidative damage caused by mitochondrial free radicals leads to aging has
brought mitochondria into the forefront of aging research. Psychological stress that …

Abstract N6‐methyladenosine (m6A) is a dynamic and reversible RNA modification that has
emerged as a crucial player in the life cycle of RNA, thus playing a pivotal role in various …

Diverse individuals age at different rates and display variable susceptibilities to tissue aging,
functional decline and aging-related diseases. Centenarians, exemplifying extreme …