Polycystic ovary syndrome (PCOS) is among the most common disorders in women of
reproductive age, affecting up to 15% worldwide, depending on the diagnostic criteria …

Genome-wide association studies (GWAS) involve testing genetic variants across the
genomes of many individuals to identify genotype–phenotype associations. GWAS have …

Gene–environment correlations affect associations between genetic variants and complex
traits in genome-wide association studies (GWASs). Here we showed in up to 43,516 British …

Hypertension, the leading risk factor for cardiovascular disease, originates from combined
genetic, environmental, and social determinants. Environmental factors include …

False positives in a Genome-Wide Association Study (GWAS) can be effectively controlled
by a fixed effect and random effect Mixed Linear Model (MLM) that incorporates population …

Big datasets, accumulated from biomedical and agronomic studies, provide the potential to
identify genes that control complex human diseases and agriculturally important traits …

Genetic architecture describes the characteristics of genetic variation that are responsible for
heritable phenotypic variability. It depends on the number of genetic variants affecting a trait …

Host genetics and the gut microbiome can both influence metabolic phenotypes. However,
whether host genetic variation shapes the gut microbiome and interacts with it to affect host …

Candidate gene and genome-wide association studies (GWAS) have identified genetic
variants that modulate risk for human disease; many of these associations require further …

Discriminating the gene target of a distal regulatory element from other nearby transcribed
genes is a challenging problem with the potential to illuminate the causal underpinnings of …