Addressing the benefits of inhibiting APOBEC3-dependent mutagenesis in cancer
Mutational signatures associated with apolipoprotein B mRNA-editing enzyme catalytic
polypeptide-like (APOBEC) 3 cytosine deaminase activity have been found in over half of …
polypeptide-like (APOBEC) 3 cytosine deaminase activity have been found in over half of …
[HTML][HTML] Therapeutic and prognostic insights from the analysis of cancer mutational signatures
The somatic mutations in each cancer genome are caused by multiple mutational
processes, each of which leaves a characteristic imprint (or 'signature'), potentially caused …
processes, each of which leaves a characteristic imprint (or 'signature'), potentially caused …
[HTML][HTML] Mechanisms of APOBEC3 mutagenesis in human cancer cells
M Petljak, A Dananberg, K Chu, EN Bergstrom… - Nature, 2022 - nature.com
The APOBEC3 family of cytosine deaminases has been implicated in some of the most
prevalent mutational signatures in cancer,–. However, a causal link between endogenous …
prevalent mutational signatures in cancer,–. However, a causal link between endogenous …
[HTML][HTML] Loss of SYNCRIP unleashes APOBEC-driven mutagenesis, tumor heterogeneity, and AR-targeted therapy resistance in prostate cancer
Tumor mutational burden and heterogeneity has been suggested to fuel resistance to many
targeted therapies. The cytosine deaminase APOBEC proteins have been implicated in the …
targeted therapies. The cytosine deaminase APOBEC proteins have been implicated in the …
[HTML][HTML] Genomic mapping of metastatic organotropism in lung adenocarcinoma
Summary We analyzed 2,532 lung adenocarcinomas (LUAD) to identify the
clinicopathological and genomic features associated with metastasis, metastatic burden …
clinicopathological and genomic features associated with metastasis, metastatic burden …
Cellular APOBEC3A deaminase drives mutations in the SARS-CoV-2 genome
Y Nakata, H Ode, M Kubota, T Kasahara… - Nucleic Acids …, 2023 - academic.oup.com
The number of genetic variations in the SARS-CoV-2 genome has been increasing primarily
due to continuous viral mutations. Here, we report that the human APOBEC3A (A3A) cytidine …
due to continuous viral mutations. Here, we report that the human APOBEC3A (A3A) cytidine …
[HTML][HTML] Accelerated evolution of SARS-CoV-2 in free-ranging white-tailed deer
The zoonotic origin of the COVID-19 pandemic virus highlights the need to fill the vast gaps
in our knowledge of SARS-CoV-2 ecology and evolution in non-human hosts. Here, we …
in our knowledge of SARS-CoV-2 ecology and evolution in non-human hosts. Here, we …
APOBEC3A induces DNA gaps through PRIMPOL and confers gap-associated therapeutic vulnerability
Mutation signatures associated with apolipoprotein B mRNA editing catalytic polypeptide-
like 3A/B (APOBEC3A/B) cytidine deaminases are prevalent across cancers, implying their …
like 3A/B (APOBEC3A/B) cytidine deaminases are prevalent across cancers, implying their …
[HTML][HTML] Prospectively defined patterns of APOBEC3A mutagenesis are prevalent in human cancers
Mutational signatures defined by single base substitution (SBS) patterns in cancer have
elucidated potential mutagenic processes that contribute to malignancy. Two prevalent …
elucidated potential mutagenic processes that contribute to malignancy. Two prevalent …
[HTML][HTML] APOBEC3-mediated mutagenesis in cancer: causes, clinical significance and therapeutic potential
K Butler, AR Banday - Journal of Hematology & Oncology, 2023 - Springer
Apolipoprotein B mRNA-editing enzyme, catalytic polypeptides (APOBECs) are cytosine
deaminases involved in innate and adaptive immunity. However, some APOBEC family …
deaminases involved in innate and adaptive immunity. However, some APOBEC family …