Ferroptosis, necroptosis, and pyroptosis in the tumor microenvironment: Perspectives for immunotherapy of SCLC
X Niu, L Chen, Y Li, Z Hu, F He - Seminars in Cancer Biology, 2022 - Elsevier
Small cell lung cancer (SCLC) is an aggressive form of lung cancer characterized by dismal
prognosis. Although SCLC may initially respond well to platinum-based chemotherapy, it …
prognosis. Although SCLC may initially respond well to platinum-based chemotherapy, it …
Therapeutic implications of tumor microenvironment in lung cancer: focus on immune checkpoint blockade
C Genova, C Dellepiane, P Carrega… - Frontiers in …, 2022 - frontiersin.org
In the last decade, the treatment of non-small cell lung cancer (NSCLC) has been
revolutionized by the introduction of immune checkpoint inhibitors (ICI) directed against …
revolutionized by the introduction of immune checkpoint inhibitors (ICI) directed against …
GSCA: an integrated platform for gene set cancer analysis at genomic, pharmacogenomic and immunogenomic levels
Cancer initiation and progression are likely caused by the dysregulation of biological
pathways. Gene set analysis (GSA) could improve the signal-to-noise ratio and identify …
pathways. Gene set analysis (GSA) could improve the signal-to-noise ratio and identify …
Tumour DDR1 promotes collagen fibre alignment to instigate immune exclusion
Immune exclusion predicts poor patient outcomes in multiple malignancies, including triple-
negative breast cancer (TNBC). The extracellular matrix (ECM) contributes to immune …
negative breast cancer (TNBC). The extracellular matrix (ECM) contributes to immune …
GEPIA2021: integrating multiple deconvolution-based analysis into GEPIA
C Li, Z Tang, W Zhang, Z Ye, F Liu - Nucleic Acids Research, 2021 - academic.oup.com
In 2017, we released GEPIA (Gene Expression Profiling Interactive Analysis) webserver to
facilitate the widely used analyses based on the bulk gene expression datasets in the TCGA …
facilitate the widely used analyses based on the bulk gene expression datasets in the TCGA …
IOBR: multi-omics immuno-oncology biological research to decode tumor microenvironment and signatures
Recent advances in next-generation sequencing (NGS) technologies have triggered the
rapid accumulation of publicly available multi-omics datasets. The application of integrated …
rapid accumulation of publicly available multi-omics datasets. The application of integrated …
Germline variants associated with toxicity to immune checkpoint blockade
Immune checkpoint inhibitors (ICIs) have yielded remarkable responses but often lead to
immune-related adverse events (irAEs). Although germline causes for irAEs have been …
immune-related adverse events (irAEs). Although germline causes for irAEs have been …
[HTML][HTML] Siglec15 shapes a non-inflamed tumor microenvironment and predicts the molecular subtype in bladder cancer
Rationale: Siglec15 is an emerging target for normalization cancer immunotherapy.
However, pan-cancer anti-Siglec15 treatment is not yet validated and the potential role of …
However, pan-cancer anti-Siglec15 treatment is not yet validated and the potential role of …
[HTML][HTML] CD276 expression enables squamous cell carcinoma stem cells to evade immune surveillance
Immunosurveillance is a critical mechanism guarding against tumor development and
progression. Checkpoint inhibitors have shown significant success in cancer treatment, but …
progression. Checkpoint inhibitors have shown significant success in cancer treatment, but …
Crosstalk between 5-methylcytosine and N6-methyladenosine machinery defines disease progression, therapeutic response and pharmacogenomic landscape in …
Y Tian, H Xiao, Y Yang, P Zhang, J Yuan, W Zhang… - Molecular cancer, 2023 - Springer
Background Accumulated evidence highlights the significance of the crosstalk between
epigenetic and epitranscriptomic mechanisms, notably 5-methylcytosine (5mC) and N6 …
epigenetic and epitranscriptomic mechanisms, notably 5-methylcytosine (5mC) and N6 …