Glucagon-like peptide 1 (GLP-1) is a 30-amino acid peptide hormone produced in the
intestinal epithelial endocrine L-cells by differential processing of proglucagon, the gene …

Incretins are gut hormones that are secreted from enteroendocrine cells into the blood within
minutes after eating. One of their many physiological roles is to regulate the amount of …

We report the discovery and translational therapeutic efficacy of a peptide with potent,
balanced co-agonism at both of the receptors for the incretin hormones glucagon-like …

Objective Structurally-improved GIP analogs were developed to determine precisely
whether GIP receptor (GIPR) agonism or antagonism lowers body weight in obese mice …

Background Glucose-dependent insulinotropic peptide (GIP) is one of two incretin hormones
that communicate nutrient intake with systemic metabolism. Although GIP was the first …

Pancreatic development represents a fascinating process in which two morphologically
distinct tissue types must derive from one simple epithelium. These two tissue types …

Introduction Obesity is recognized as a major healthcare challenge. Following years of slow
progress in discovery of safe, effective therapies for weight management, recent approval of …

OBJECTIVE—To examine the mechanisms of action, therapeutic potential, and challenges
inherent in the use of incretin peptides and dipeptidyl peptidase-IV (DPP-IV) inhibitors for the …

Background Nonalcoholic fatty liver disease (NAFLD) is a known outcome of
hepatosteatosis. Free fatty acids (FFA) induce the unfolded protein response (UPR) or …

Glucagon-like peptide-1 (GLP-1) is an intestinal hormone that is secreted during meal
absorption and is essential for normal glucose homeostasis. However, the relatively low …