Recent advances in oligonucleotide therapeutics in oncology

H Xiong, RN Veedu, SD Diermeier - International Journal of Molecular …, 2021 - mdpi.com
Cancer is one of the leading causes of death worldwide. Conventional therapies, including
surgery, radiation, and chemotherapy have achieved increased survival rates for many types …

Small interfering RNA: Discovery, pharmacology and clinical development—An introductory review

P Ranasinghe, ML Addison, JW Dear… - British Journal of …, 2023 - Wiley Online Library
Post‐transcriptional gene silencing targets and degrades mRNA transcripts, silencing the
expression of specific genes. RNA interference technology, using synthetic structurally well …

siRNA therapeutics: a clinical reality

PE Saw, EW Song - Science China Life Sciences, 2020 - Springer
Since the revolutionary discovery of RNA interference (RNAi), a remarkable progress has
been achieved in understanding and harnessing gene silencing mechanism; especially in …

Non-coding RNAs in cardiovascular diseases: diagnostic and therapeutic perspectives

W Poller, S Dimmeler, S Heymans, T Zeller… - European heart …, 2018 - academic.oup.com
Recent research has demonstrated that the non-coding genome plays a key role in genetic
programming and gene regulation during development as well as in health and …

[HTML][HTML] Nanotechnology advances in the detection and treatment of cancer: an overview

S Mosleh-Shirazi, M Abbasi, M reza Moaddeli… - …, 2022 - ncbi.nlm.nih.gov
Over the last few years, progress has been made across the nanomedicine landscape, in
particular, the invention of contemporary nanostructures for cancer diagnosis and …

The potential role of miRNAs in the pathogenesis of cardiovascular diseases–A focus on signaling pathways interplay

EG Khidr, AI Abulsoud, AA Doghish… - … -Research and Practice, 2023 - Elsevier
For the past two decades since their discovery, scientists have linked microRNAs (miRNAs)
to posttranscriptional regulation of gene expression in critical cardiac physiological and …

Exosomal microRNAs derived from mesenchymal stem cells: cell-to-cell messages

K Asgarpour, Z Shojaei, F Amiri, J Ai… - Cell Communication and …, 2020 - Springer
Exosomes are extracellular vesicles characterized by their size, source, release mechanism
and contents. MicroRNAs (miRNAs) are single stranded non-coding RNAs transcribed from …

Recent progress in development of siRNA delivery vehicles for cancer therapy

HJ Kim, A Kim, K Miyata, K Kataoka - Advanced drug delivery reviews, 2016 - Elsevier
Recent progress in RNA biology has broadened the scope of therapeutic targets of RNA
drugs for cancer therapy. However, RNA drugs, typically small interfering RNAs (siRNAs) …

A perspective on oligonucleotide therapy: Approaches to patient customization

S Thakur, A Sinhari, P Jain, HR Jadhav - Frontiers in Pharmacology, 2022 - frontiersin.org
It is estimated that the human genome encodes 15% of proteins that are considered to be
disease-modifying. Only 2% of these proteins possess a druggable site that the approved …

Stem cell therapy in heart diseases–cell types, mechanisms and improvement strategies

P Müller, H Lemcke, R David - Cellular Physiology and Biochemistry, 2018 - karger.com
A large number of clinical trials have shown stem cell therapy to be a promising therapeutic
approach for the treatment of cardiovascular diseases. Since the first transplantation into …