Fundamentals of siRNA and miRNA therapeutics and a review of targeted nanoparticle delivery systems in breast cancer

T Ahmadzada, G Reid, DR McKenzie - Biophysical reviews, 2018 - Springer
Gene silencing via RNA interference (RNAi) is rapidly evolving as a personalized approach
to cancer treatment. The effector molecules—small interfering RNAs (siRNAs) and …

The reversal of chemotherapy-induced multidrug resistance by nanomedicine for cancer therapy

S Liu, AR Khan, X Yang, B Dong, J Ji, G Zhai - Journal of Controlled …, 2021 - Elsevier
Multidrug resistance (MDR) of cancer is a persistent problem in chemotherapy. Scientists
have considered the overexpressed efflux transporters responsible for MDR and …

Exosome-mediated small RNA delivery: a novel therapeutic approach for inflammatory lung responses

D Zhang, H Lee, X Wang, A Rai, M Groot, Y Jin - Molecular Therapy, 2018 - cell.com
Exosomes (EXOs) are a type of extracellular nanovesicles released from living cells.
Accumulating evidence suggests that EXOs are involved in the pathogenesis of human …

[HTML][HTML] The neurobiology of non-coding RNAs and Alzheimer's disease pathogenesis: Pathways, mechanisms and translational opportunities

E Lauretti, K Dabrowski, D Praticò - Ageing Research Reviews, 2021 - Elsevier
In the past two decades, advances in sequencing technology and analysis of the human and
mouse genome have led to the discovery of many non-protein-coding RNAs (ncRNAs) …

The new era of nanotechnology, an alternative to change cancer treatment

A Jurj, C Braicu, LA Pop, C Tomuleasa… - Drug design …, 2017 - Taylor & Francis
In the last few years, nanostructures have gained considerable interest for the safe delivery
of therapeutic agents. Several therapeutic approaches have been reported, such as …

Gene therapy to enhance angiogenesis in chronic wounds

E Shaabani, M Sharifiaghdam, R Faridi-Majidi… - … Therapy-Nucleic Acids, 2022 - cell.com
Skin injuries and chronic non-healing wounds are one of the major global burdens on the
healthcare systems worldwide due to their difficult-to-treat nature, associated co-morbidities …

Innovative approaches in transforming microRNAs into therapeutic tools

AFA Samad, MF Kamaroddin - Wiley Interdisciplinary Reviews …, 2023 - Wiley Online Library
MicroRNA (miRNA) is regarded as a prominent genetic regulator, as it can fine‐tune an
entire biological pathway by targeting multiple target genes. This characteristic makes …

Insights into oxidative stress in bone tissue and novel challenges for biomaterials

G Cerqueni, A Scalzone, C Licini, P Gentile… - Materials Science and …, 2021 - Elsevier
Abstract The presence of Reactive Oxygen Species (ROS) in bone can influence resident
cells behaviour as well as the extra-cellular matrix composition and the tissue architecture …

Monkeypox outbreak 2022: What we know so far and its potential drug targets and management strategies

AA Rabaan, AH Abas, TE Tallei… - Journal of Medical …, 2023 - Wiley Online Library
Monkeypox is a rare zoonotic disease caused by infection with the monkeypox virus. The
disease can result in flu‐like symptoms, fever, and a persistent rash. The disease is currently …

Inhibitors of connexin and pannexin channels as potential therapeutics

J Willebrords, M Maes, SC Yanguas… - Pharmacology & …, 2017 - Elsevier
While gap junctions support the exchange of a number of molecules between neighboring
cells, connexin hemichannels provide communication between the cytosol and the …