Plant-derived edible nanoparticles and miRNAs: emerging frontier for therapeutics and targeted drug-delivery
Rigorous and timely studies have been conducted to develop natural and green
nanomedicines wherein plant-derived edible nanoparticles (PDENs) have a great potential …
nanomedicines wherein plant-derived edible nanoparticles (PDENs) have a great potential …
RNA cancer nanomedicine: nanotechnology-mediated RNA therapy
It has been demonstrated that RNA molecules—mRNA, siRNA, microRNA, and sgRNA—
regulate cancer-specific genes, and therefore, RNA-based therapeutics can suppress tumor …
regulate cancer-specific genes, and therefore, RNA-based therapeutics can suppress tumor …
Engineering gene therapy: advances and barriers
A Shahryari, I Burtscher, Z Nazari… - Advanced …, 2021 - Wiley Online Library
Abstract Currently, 33 gene‐therapy drugs/products have been approved in the clinic. Over
3000 completed and ongoing clinical gene therapy trials have been reported worldwide …
3000 completed and ongoing clinical gene therapy trials have been reported worldwide …
Lipid Nanoparticle (LNP) Chemistry Can Endow Unique In Vivo RNA Delivery Fates within the Liver That Alter Therapeutic Outcomes in a Cancer Model
LT Johnson, D Zhang, K Zhou, SM Lee… - Molecular …, 2022 - ACS Publications
Within the field of lipid nanoparticles (LNPs) for RNA delivery, the focus has been mainly
placed on organ level delivery, which can mask cellular level effects consequential to …
placed on organ level delivery, which can mask cellular level effects consequential to …
Leveraging physiology for precision drug delivery
Physiological characteristics of diseases bring about both challenges and opportunities for
targeted drug delivery. Various drug delivery platforms have been devised ranging from …
targeted drug delivery. Various drug delivery platforms have been devised ranging from …
Lipid nanoparticles for nucleic acid delivery to endothelial cells
GW Liu, EB Guzman, N Menon, RS Langer - Pharmaceutical Research, 2023 - Springer
Endothelial cells play critical roles in circulatory homeostasis and are also the gateway to
the major organs of the body. Dysfunction, injury, and gene expression profiles of these cells …
the major organs of the body. Dysfunction, injury, and gene expression profiles of these cells …
Nebulization of extracellular vesicles: a promising small RNA delivery approach for lung diseases
Small extracellular vesicles (sEVs) are a group of cell-secreted nanovesicles with a diameter
up to 200 nm. A growing number of studies have indicated that sEVs can reflect the …
up to 200 nm. A growing number of studies have indicated that sEVs can reflect the …
Advances in siRNA delivery approaches in cancer therapy: challenges and opportunities
Advancements in the clinical applications of small interfering RNA (siRNA) in cancer therapy
have opened up new possibilities for precision medicine. siRNAs, as powerful genetic tools …
have opened up new possibilities for precision medicine. siRNAs, as powerful genetic tools …
Lipid-polymer hybrid nanocarriers for delivering cancer therapeutics
Cancer remained a major cause of death providing diversified challenges in terms of
treatment including non-specific toxicity, chemoresistance and relapse. Nanotechnology …
treatment including non-specific toxicity, chemoresistance and relapse. Nanotechnology …
Nucleic acid drug vectors for diagnosis and treatment of brain diseases
ZG Lu, J Shen, J Yang, JW Wang, RC Zhao… - … and Targeted Therapy, 2023 - nature.com
Nucleic acid drugs have the advantages of rich target selection, simple in design, good and
enduring effect. They have been demonstrated to have irreplaceable superiority in brain …
enduring effect. They have been demonstrated to have irreplaceable superiority in brain …