A multifunctional scaffold for bone infection treatment by delivery of microRNA therapeutics combined with antimicrobial nanoparticles

JM Sadowska, RN Power, KJ Genoud… - Advanced …, 2024 - Wiley Online Library
Treating bone infections and ensuring bone repair is one of the greatest global challenges
of modern orthopedics, made complex by antimicrobial resistance (AMR) risks due to long …

Advancements in regenerative strategies through the continuum of burn care

R Stone II, S Natesan, CJ Kowalczewski… - Frontiers in …, 2018 - frontiersin.org
Burns are caused by several mechanisms including flame, scald, chemical, electrical, and
ionizing and non-ionizing radiation. Approximately half a million burn cases are registered …

Chitosan-based nanoparticles for nucleic acid delivery: technological aspects, applications, and future perspectives

M Karayianni, T Sentoukas, A Skandalis, N Pippa… - Pharmaceutics, 2023 - mdpi.com
Chitosan is a naturally occurring polymer derived from the deacetylation of chitin, which is
an abundant carbohydrate found mainly in the shells of various marine and terrestrial …

[图书][B] Applied animal endocrinology

EJ Squires - 2024 - cabidigitallibrary.org
This book explains the role of hormones in improving and monitoring the production,
performance, reproduction, behaviour and health of livestock animals, focusing on cattle …

[HTML][HTML] Construction of a guide-RNA for site-directed RNA mutagenesis utilising intracellular A-to-I RNA editing

M Fukuda, H Umeno, K Nose, A Nishitarumizu… - Scientific reports, 2017 - nature.com
As an alternative to DNA mutagenesis, RNA mutagenesis can potentially become a powerful
gene-regulation method for fundamental research and applied life sciences. Adenosine-to …

RNA-targeted therapeutics in cancer clinical trials: Current status and future directions

P Barata, AK Sood, DS Hong - Cancer treatment reviews, 2016 - Elsevier
Recent advances in RNA delivery and target selection provide unprecedented opportunities
for cancer treatment, especially for cancers that are particularly hard to treat with existing …

siRNA therapeutics against respiratory viral infections—What have we learned for potential COVID‐19 therapies?

A Mehta, T Michler, OM Merkel - Advanced healthcare materials, 2021 - Wiley Online Library
Acute viral respiratory tract infections (AVRIs) are a major burden on human health and
global economy and amongst the top five causes of death worldwide resulting in an …

Inhibition of microRNA-210 suppresses pro-inflammatory response and reduces acute brain injury of ischemic stroke in mice

L Huang, Q Ma, Y Li, B Li, L Zhang - Experimental neurology, 2018 - Elsevier
Stroke is a leading cause of mortality and chronic neurologic disability. Yet, the successful
treatment remains limited. In this study, we investigated the efficacy and the mechanism of a …

miRNA delivery by nanosystems: state of the art and perspectives

FC Moraes, C Pichon, D Letourneur, F Chaubet - Pharmaceutics, 2021 - mdpi.com
MicroRNAs (miRNAs) are short (~ 21–23 nucleotides), non-coding endogenous RNA
molecules that modulate gene expression at the post-transcriptional level via the …

Gene therapy for hearing loss

R Omichi, SB Shibata, CC Morton… - Human molecular …, 2019 - academic.oup.com
Sensorineural hearing loss (SNHL) is the most common sensory disorder. Its underlying
etiologies include a broad spectrum of genetic and environmental factors that can lead to …