Ulcerative colitis (UC) is a chronic non-specific inflammatory bowel disease, which usually
manifests as abdominal pain, diarrhea and hematochezia. The disease often recurs and is …

Gene therapy is a promising novel method of tissue regeneration by stimulating or inhibiting
key signaling pathways. However, their therapeutic applications in vivo are largely limited by …

Viral infections are a great threat to human health. Currently, there are no effective vaccines
and antiviral drugs against the majority of viral diseases, suggesting the need to develop …

Cadherin-6 (CDH6) is aberrantly expressed in cancer and closely associated with tumor
progression. However, the functions of CDH6 in human osteosarcoma and the molecular …

Triple negative breast cancer (TNBC) is an aggressive type of breast cancer characterized
by the absence of defined molecular targets, including estrogen receptor (ER), progesterone …

Cancer is a genetic disease originating from the accumulation of gene mutations in a
cellular subpopulation. Although many therapeutic approaches have been developed to …

Disruption of the epigenetic program of gene expression is a hallmark of cancer that initiates
and propagates tumorigenesis. Altered DNA methylation, histone modifications and ncRNAs …

17β-Estradiol (E2) plays a pivotal role in the development and progression of breast cancer.
As a result, blockade of the E2 signal through either tamoxifen (TAM) or aromatase inhibitors …

The lack of an appropriate intracellular delivery system for therapeutic nucleic acids (TNAs)
is a major problem in molecular biology, biotechnology, and medicine. A relatively new class …

Gastrointestinal (GI) vagal afferents convey sensory signals from the GI tract to the brain.
Numerous subtypes of GI vagal afferent have been identified but their individual roles in gut …