Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

H Sies, DP Jones - Nature reviews Molecular cell biology, 2020 - nature.com
Abstract 'Reactive oxygen species'(ROS) is an umbrella term for an array of derivatives of
molecular oxygen that occur as a normal attribute of aerobic life. Elevated formation of the …

Physiological signaling functions of reactive oxygen species in stem cells: from flies to man

SA Sinenko, TY Starkova, AA Kuzmin… - Frontiers in cell and …, 2021 - frontiersin.org
Reactive oxygen species (ROS), superoxide anion and hydrogen peroxide, are generated
as byproducts of oxidative phosphorylation in the mitochondria or via cell signaling-induced …

Selenium and selenoproteins in health

F Zhang, X Li, Y Wei - Biomolecules, 2023 - mdpi.com
Selenium is a trace mineral that is essential for health. After being obtained from food and
taken up by the liver, selenium performs various physiological functions in the body in the …

Exploration of nanozymes in viral diagnosis and therapy

J Lee, H Liao, Q Wang, J Han, JH Han, HE Shin… - …, 2022 - Wiley Online Library
Nanozymes are nanomaterials with similar catalytic activities to natural enzymes. Compared
with natural enzymes, they have numerous advantages, including higher physiochemical …

Mitochondrial management of reactive oxygen species

G Napolitano, G Fasciolo, P Venditti - Antioxidants, 2021 - mdpi.com
Mitochondria in aerobic eukaryotic cells are both the site of energy production and the
formation of harmful species, such as radicals and other reactive oxygen species, known as …

ROS regulated reversible protein phase separation synchronizes plant flowering

X Huang, S Chen, W Li, L Tang, Y Zhang… - Nature Chemical …, 2021 - nature.com
How aerobic organisms exploit inevitably generated but potentially dangerous reactive
oxygen species (ROS) to benefit normal life is a fundamental biological question. Locally …

The superoxide radical switch in the biology of nitric oxide and peroxynitrite

L Piacenza, A Zeida, M Trujillo… - Physiological …, 2022 - journals.physiology.org
The free radical nitric oxide (· NO) is a key mediator in different physiological processes such
as vasodilation, neurotransmission, inflammation, and cellular immune responses, and thus …

How do metalloproteins tame the Fenton reaction and utilize• OH radicals in constructive manners?

B Wang, X Zhang, W Fang, C Rovira… - Accounts of Chemical …, 2022 - ACS Publications
Conspectus This Account describes the manner whereby nature controls the Fenton-type
reaction of O–O homolysis of hydrogen peroxide and harnesses it to carry out various useful …

Interplay of carbon dioxide and peroxide metabolism in mammalian cells

R Radi - Journal of Biological Chemistry, 2022 - ASBMB
The carbon dioxide/bicarbonate (CO 2/HCO 3-) molecular pair is ubiquitous in mammalian
cells and tissues, mainly as a result of oxidative decarboxylation reactions that occur during …

Role of oxidative stress in calcific aortic valve disease and its therapeutic implications

HZE Greenberg, G Zhao, AM Shah… - Cardiovascular …, 2022 - academic.oup.com
Calcific aortic valve disease (CAVD) is the end result of active cellular processes that lead to
the progressive fibrosis and calcification of aortic valve leaflets. In western populations …