From target discovery to clinical drug development with human genetics
The substantial investments in human genetics and genomics made over the past three
decades were anticipated to result in many innovative therapies. Here we investigate the …
decades were anticipated to result in many innovative therapies. Here we investigate the …
Genetics of chronic respiratory disease
Chronic respiratory diseases, such as chronic obstructive pulmonary disease (COPD),
asthma and interstitial lung diseases are frequently occurring disorders with a polygenic …
asthma and interstitial lung diseases are frequently occurring disorders with a polygenic …
[HTML][HTML] Circulating proteins to predict COVID-19 severity
CY Su, S Zhou, E Gonzalez-Kozlova… - Scientific Reports, 2023 - nature.com
Predicting COVID-19 severity is difficult, and the biological pathways involved are not fully
understood. To approach this problem, we measured 4701 circulating human protein …
understood. To approach this problem, we measured 4701 circulating human protein …
[HTML][HTML] Multi-omic insight into the molecular networks of mitochondrial dysfunction in the pathogenesis of inflammatory bowel disease
Background Mitochondrial dysfunction has been linked to the development of inflammatory
bowel disease (IBD), but the genetic pathophysiology was not fully elucidated. We employed …
bowel disease (IBD), but the genetic pathophysiology was not fully elucidated. We employed …
[HTML][HTML] Alternative splicing in lung influences COVID-19 severity and respiratory diseases
Alternative splicing generates functional diversity in isoforms, impacting immune response to
infection. Here, we evaluate the causal role of alternative splicing in COVID-19 severity and …
infection. Here, we evaluate the causal role of alternative splicing in COVID-19 severity and …
Genetic predisposition to subjective well-being, depression, and suicide in relation to COVID-19 susceptibility and severity
H Song, N Lei, L Zeng, X Li, X Li, Y Liu, J Liu… - Journal of affective …, 2023 - Elsevier
Background Epidemiological studies have reported associations between subjective well-
being (SWB), depression, and suicide with COVID-19 illness, but the causality has not been …
being (SWB), depression, and suicide with COVID-19 illness, but the causality has not been …
COL6A3-derived endotrophin mediates the effect of obesity on coronary artery disease: an integrative proteogenomics analysis
Obesity strongly increases the risk of cardiometabolic diseases, yet the underlying mediators
of this relationship are not fully understood. Given that obesity has broad effects on …
of this relationship are not fully understood. Given that obesity has broad effects on …
[HTML][HTML] Proteomic insights into the associations between obesity, lifestyle factors, and coronary artery disease
Background We aimed to investigate the protein pathways linking obesity and lifestyle
factors to coronary artery disease (CAD). Methods Summary-level genome-wide association …
factors to coronary artery disease (CAD). Methods Summary-level genome-wide association …
Gut microbiota and cognitive performance: A bidirectional two-sample Mendelian randomization
Q Wang, Y Song, X Wu, Y Luo, R Miao, X Yu… - Journal of Affective …, 2024 - Elsevier
Purpose Previous studies have suggested a potential association between gut microbiota
and neurological and psychiatric disorders. However, the causal relationship between gut …
and neurological and psychiatric disorders. However, the causal relationship between gut …
Causal Relationships Between Screen Use, Reading, and Brain Development in Early Adolescents
The rise of new media has greatly changed the lifestyles, leading to increased time on these
platforms and less time spent reading. This shift has particularly profound impacts on early …
platforms and less time spent reading. This shift has particularly profound impacts on early …