Ninety percent of clinical drug development fails despite implementation of many successful
strategies, which raised the question whether certain aspects in target validation and drug …

Ozone–a powerful antimicrobial agent, has been extensively applied for decontamination
purposes in several industries (including food, water treatment, pharmaceuticals, textiles …

Chimeric Antigen Receptor T Cells This review addresses T-cell engineering and synthetic
immunity, with a focus on producing durable remissions in patients with treatment-refractory …

Effective adoptive T cell therapy (ACT) comprises the killing of cancer cells through the
therapeutic use of transferred T cells. One of the main ACT approaches is chimeric antigen …

More than four decades have passed since the first example of a light-activated (caged)
compound was described. In the intervening years, a large number of light-responsive …

For decades, preclinical toxicology was essentially a descriptive discipline in which
treatment-related effects were carefully reported and used as a basis to calculate safety …

Photopharmacology is an attractive approach for achieving targeted drug action with the use
of light. In photopharmacology, molecular photoswitches are introduced into the structure of …

Liver biology and function, drug-induced liver injury (DILI) and liver diseases are difficult to
study using current in vitro models such as primary human hepatocyte (PHH) monolayer …

Improving the effectiveness of preclinical predictions of human drug responses is critical to
reducing costly failures in clinical trials. Recent advances in cell biology, microfabrication …

Immune effector cells, including T cells and natural killer cells, which are genetically
engineered to express a chimeric antigen receptor (CAR), constitute a powerful new class of …