A decade ago, gene expression profiling (GEP) was successfully introduced in
haematological research. Considering the heterogeneity of haematological malignancies …

Despite impressive advances in cure rates for childhood acute lymphoblastic leukemia
(ALL), ALL remains the leading cause of disease-related death in young people and new …

Background Haematological malignancies harbouring rearrangements of the KMT2A gene
represent a unique subtype of leukaemia, with biphenotypic clinical manifestations, a rapid …

PAX5 encodes for a transcription factor essential for B-lymphoid cell commitment and is
rearranged in 30% of B-cell precursor acute lymphoblastic leukemia pediatric patients (BCP …

This report presents the outcomes of a systematic review (SR) identifying the mechanisms
and chemicals involved in the pathogenesis of Parkinson's disease (PD) and childhood …

AIM: Observation of identical genetic changes in leukemia cells from monozygotic twin pairs
has provided evidence for the in utero single clonal origin hypothesis of leukemia, with …

While more than 80% of children with acute lymphoblastic leukemia (ALL) are cured with
current chemotherapeutic regimens, a significant proportion of this patient population is at …

Telomere transcription into telomeric repeat-containing RNA (TERRA) is an integral
component of all aspects of chromosome end protection consisting of telomerase-or …

The occurrence of leukemia in twins is rare but has a crucial implication in the genetic
research of leukemia. This report presents 2 pairs of monozygotic twins with precursor B-cell …

Genes related to key cellular pathways are frequently altered in B cell ALL and are
associated with poor survival especially in high-risk (HR) subgroups. We examined gene …