Recently, PAX5 has been identified as a frequent target of mutation in BCP-ALL (around
30%). Among them 25% of the cases report deletions, 7% point mutations and 2-3 …

DEPARTAMENTO DE BIOQUÍMICA Y BIOLOGÍA MOLECULAR III E INMUNOLOGÍA PROGRAMA
DE BIOMEDICINA TESIS DOCTORAL LEUCEMIA LINFOBLÁST Page 1 DEPARTAMENTO DE …

Die chromosomale Translokation t (12; 21), aus der das Fusionsgen ETV6/RUNX1 entsteht,
ist die häufigste interchromosomale Veränderung bei der B-Vorläuferzell-(B-cell precursor …

Despite high cure rates achieved in the last two decades, treatment resistance and therapy-
associated toxicity is still observed in a significant proportion of children with ALL, warranting …

Continuous renewal of blood cells, so called hematopoiesis, is essential for human life.
Starting from several months after birth the majority of blood cell production occurs in the …

La Leucemia Linfoblástica Aguda (LLA) es el cáncer pediátrico más común. Es un desorden
de las células linfoblásticas, que son las precursoras de las células linfáticas, y se …

ETV6-RUNX1 is the most common chromosomal alteration in pediatric B cell acute
lymphoblastic leukemia. ETV6-RUNX1 represses RUNX1 target genes. However, little is …

B-lymphopoiesis is characterised by orderly progression through a series of stages of
differentiation, each of which is associated with specific patterns of protein expression and …

V diagnostice a léčbě dětské akutní lymfoblastické leukémie (ALL) bylo během několika
uplynulých desetiletí dosaženo vynikajících úspěchů a procento trvale vyléčených dětí a …

Correspondence: Shaji R Velayudhan, Ph. D., Department of Haematology, Christian
Medical College, Vellore-632004, India. Phone: international+ 416.2283564/4114. Fax …